Sep 15, 2005

Association between tau H2 haplotype and age at onset in frontotemporal dementia

Archives of Neurology
B BorroniMaria Grazia Spillantini

Abstract

The frontotemporal dementia (FTD) syndromes have been associated with the microtubule-associated tau protein since tau gene mutations have been demonstrated to be the cause of FTD and parkinsonism linked to chromosome 17. In cases of FTD without tau gene mutations, however, it is unclear whether genetic variability in the tau gene is associated with the development or modulation of FTD. To determine whether genetic variability in tau and apolipoprotein E (ApoE) modulates and contributes to the development of FTD. Design and Patients The distribution of tau gene haplotypes and the ApoE genotype were investigated in 86 patients with well-characterized FTD and 50 control subjects. No difference in the distribution of the tau H1 and H2 haplotypes between FTD cases and controls was observed, whereas the ApoE epsilon4 allele was more frequent in FTD cases. The presence of at least 1 tau H2 allele was found to be significantly associated with an earlier age of onset in patients with FTD. The association between the H2 allele and age at onset was not related to family history, clinical presentation, or ApoE genotype. These findings support a role of tau protein in modulating disease phenotype by influencing the age at onset in these FT...Continue Reading

  • References
  • Citations21

References

  • We're still populating references for this paper, please check back later.

Mentioned in this Paper

Senile Paranoid Dementia
Family Health Status
Gene Mutation
Sequence Determinations
Parkinsonian Disorders
Microtubules
Late Onset Disorders
Apolipoprotein E Isoproteins
Tau Proteins
Chromosomes, Human, Pair 17

Related Feeds

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.

Alzheimer's Disease: APOE

Apolipoprotein E (APOE) polymorphic alleles are major genetic risk factors for Alzheimer's Disease. Discover the latest research on APOE and other genetic determinants of Alzheimer's Disease here.