Association between telomere length and complete blood count in US adults

Archives of Medical Science : AMS
Mohsen MazidiMaciej Banach

Abstract

Telomere length (TL) is related to age-related health outcomes, but little is known about the relationship between TL and complete blood count (CBC) parameters. We aimed to determine the relationship between TL and CBC in a sample of healthy US adults. Participants in the National Health and Nutrition Examination Survey (NHANES) recruited between 1999 and 2002 who had essential data on total CBC and TL were studied. We computed age- and race-adjusted mean values for total CBC using analysis of covariance (ANCOVA). All statistical analyses accounted for the survey design and sample weights by using SPSS Complex Samples v22.0 (IBM Corp, Armonk, NY). Of the 8892 eligible participants, 47.8% (n = 4123) were men. The mean age was 41.8 years overall, 41.0 years in men and 42.6 in women (p = 0.238). The sex-stratified ANCOVA showed no significant difference in the total CBC across TL quartiles (all p > 0.05) in both sexes. In the adjusted model, there was a significant negative relationship with monocyte count (β = -0.051, 95% CI: -0.422; -0.142), mean cell hemoglobin (β = -0.051, 95% CI: -0.038; -0.011) and red cell distribution width (β = -0.031, 95% CI: -0.054; -0.003), while there was a significant positive relationship with basop...Continue Reading

Citations

Jun 7, 2017·Angiology·Mohsen MazidiMaciej Banach
Mar 4, 2018·European Journal of Clinical Nutrition·Mohsen MazidiAndre Pascal Kengne
Jan 18, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Sonja EntringerPathik D Wadhwa
Aug 6, 2017·Lipids in Health and Disease·Mohsen MazidiAndre Pascal Kengne
Aug 7, 2017·Journal of Nutrition and Metabolism·Mohsen MazidiAndre Pascal Kengne
Sep 28, 2017·Oxidative Medicine and Cellular Longevity·Mohsen MazidiHassan Vatanparast
Jul 24, 2020·Scientific Reports·Charleen D Adams, Brian B Boutwell
Feb 24, 2021·Drug and Alcohol Dependence·Sanjay R MehtaUNKNOWN TMARC Group

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