Abstract
This is a study of the association between DRD4 exon III VNTR and DAT1 3'-untranslated region polymorphisms on the one hand and temperament assessed with the Formal Characteristics of Behaviour-Temperament Inventory on the other hand. The study was run on 418 participants (314 women and 104 men) aged 18 to 55 years sampled from healthy male and female volunteers recruited from inhabitants of the Warsaw metropolis. Main effects of sex were found for briskness (F(1,417) = 9.05, P = .003, η(2) = 0.022), perseveration (F(1,417) = 37.83, P < .001, η(2) = 0.085), sensory sensitivity (F(1,417) = 14.16, P < .001, η(2) = 0.003), and emotional reactivity (F(1,417) = 34.67, P < .001, η(2) = 0.078). A significant main effect of DAT1 variant was also found for sensory sensitivity (F(1,417) = 7.36, P = .007, η(2) = 0.018). No main effects of DRD4 on any of the analyzed temperament traits were found. A significant interaction of sex and DRD4 variant was found for sensory sensitivity (F(1,417) = 5.68, P = .018, η(2) = 0.014). No significant 3-way interactions (DAT1 × DRD4 × sex) were found. A significant main effect of DAT1 polymorphism on sensory sensitivity and a significant interactive sex/DRD4 effect on that same trait were found.
References
Jul 9, 1992·Nature·H H Van TolV Jovanovic
Dec 1, 1992·Genomics·D J VandenberghG R Uhl
Dec 1, 1993·Archives of General Psychiatry·C R CloningerT R Przybeck
Jan 1, 1996·Nature Genetics·R P EbsteinR H Belmaker
Jan 1, 1996·Nature Genetics·J BenjaminD H Hamer
Mar 24, 1997·Neuroreport·D BallR Plomin
Feb 13, 1999·The Journal of Heredity·J Ott
Jul 15, 1999·Psychological Medicine·I J DearyA Harmar
Jan 29, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·A HeinzD R Weinberger
Mar 29, 2000·Biochemistry·M A KazmiT P Sakmar
Apr 17, 2001·The Behavioral and Brain Sciences·R A Depue, P F Collins
May 8, 2001·Neuropsychobiology·J SamochowiecJ Hauser
May 30, 2001·American Journal of Medical Genetics·A F JormS Easteal
Jan 5, 2002·Proceedings of the National Academy of Sciences of the United States of America·Yuan-Chun DingRobert K Moyzis
Jan 23, 2002·Molecular Psychiatry·G M Miller, B K Madras
Mar 26, 2002·The Pharmacogenomics Journal·S FukeS Ishiura
Jun 26, 2002·Molecular Psychiatry·S Van GestelC Van Broeckhoven
Jul 16, 2002·Journal of Affective Disorders·G MarijnissenW M A Verhoeven
Nov 29, 2002·American Journal of Medical Genetics·Jonathan MillIan Craig
Apr 11, 2003·Neurogenetics·Alessandro De LucaBruno Dallapiccola
Oct 16, 2003·Genomics·Tiffany A Greenwood, John R Kelsoe
Oct 29, 2003·The Pharmacogenomics Journal·O Schoots, H H M Van Tol
Jan 28, 2004·Annual Review of Psychology·Timothy D Wilson, Elizabeth W Dunn
May 20, 2004·Psychiatry and Clinical Neurosciences·Kelley Yost AbramsIn Kyoon Lyoo
Sep 13, 2006·Neuropsychobiology·Wojciech Ł Dragan, Włodzimierz Oniszczenko
Dec 28, 2006·Yonsei Medical Journal·Se Joo KimHong Shick Lee
May 26, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Eliza CongdonTurhan Canli
Jun 19, 2007·Biological Psychiatry·Marcus R MunafòJonathan Flint
Dec 12, 2007·Cell and Tissue Research·Srinivasa SubramaniamKlaus Unsicker
Jan 15, 2008·Journal of Affective Disorders·Jee In KangSe Joo Kim
Aug 12, 2008·Behavioural Pharmacology·Kenneth A PerkinsNeal L Benowitz
Sep 26, 2008·Biological Psychiatry·Marcel RomanosManfred Gerlach
Jun 10, 2009·Human Genetics·Ian R GizerIrwin D Waldman
Oct 3, 2009·Pain·Roi TreisterElon Eisenberg
Mar 6, 2010·Social Cognitive and Affective Neuroscience·Julia DmitrievaYuan-Chun Ding
Sep 17, 2010·Human Brain Mapping·Tim HahnAndreas J Fallgatter
Aug 10, 2011·PloS One·Elena ShumayNora D Volkow
Dec 1, 2007·Perspectives on Psychological Science : a Journal of the Association for Psychological Science·Jerome Kagan
Citations
Aug 6, 2014·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Włodzimierz Oniszczenko, Wojciech Łukasz Dragan
May 28, 2015·Scandinavian Journal of Psychology·Włodzimierz OniszczenkoJerzy Samochowiec
May 6, 2020·Brain Sciences·Aleksandra SuchaneckaAnna Grzywacz
Aug 27, 2019·Frontiers in Psychology·Maria BierzynskaMalgorzata Maria Kossut
Sep 27, 2018·International Journal of Environmental Research and Public Health·Jolanta ChmielowiecAnna Grzywacz
Jun 2, 2020·Frontiers in Psychiatry·Xiaojun Shao, Gang Zhu