Abstract
CD4 (+) T helper 17 (Th17) cells play critical roles in inflammation and tumor development. The involvement of Th17 cells in chronic obstructive pulmonary disease (COPD)-type inflammation-associated lung cancer has also been confirmed in animal models. However, to the authors' knowledge, it is unknown whether the role of Th17 cells is different in patients with lung cancer complicated with COPD compared with those without COPD. In the current study, the authors attempted to determine the association between the circulating levels of Th17-related cytokines and the clinical characteristics of non-small cell lung cancer (NSCLC) in patients with or without COPD. The authors designed a matched case-control study that included 70 patients with NSCLC with COPD, 148 patients with NSCLC without COPD, and 148 healthy controls. The data regarding the clinicopathological features of these participants were collected. Circulating levels of Th17-related cytokines, including interleukin (IL) 23 (IL-23), IL-17A, IL-17F, IL-22, and tumor necrosis factor-α, were measured. The circulating levels of IL-23, IL-17A, IL-17F, IL-22, and tumor necrosis factor-α were found to be significantly higher in the patients with NSCLC compared with the healthy c...Continue Reading
References
Jun 15, 2000·The European Respiratory Journal·A LindénM Laan
Oct 16, 2004·Immunity·Jay K Kolls, Anders Lindén
Aug 23, 2007·Nature Immunology·Arian Laurence, John J O'Shea
Mar 28, 2008·Nature·Liang ZhouDan R Littman
Apr 11, 2008·Immunity·Wenjun OuyangYan Zheng
Feb 7, 2009·The European Respiratory Journal·R P YoungG D Gamble
Mar 18, 2009·Blood·Ilona KryczekWeiping Zou
Jul 17, 2009·Clinical and Experimental Immunology·A Di StefanoB Balbi
Sep 17, 2009·Primary Care Respiratory Journal : Journal of the General Practice Airways Group·Victor A KiriLeonardo Fabbri
Nov 3, 2009·Immunity·Natalia Martin-OrozcoChen Dong
Dec 22, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Xi ChenZhengtang Chen
Jul 19, 2011·Respiratory Medicine·María Inés Vargas-RojasRaúl H Sansores
Jul 26, 2011·Cancer Biology & Therapy·Ying LiHu Lun Li
Jul 30, 2011·American Journal of Respiratory and Critical Care Medicine·Juan P de TorresBartolome R Celli
Sep 19, 2012·American Journal of Epidemiology·Darren R BrennerRayjean J Hung
Oct 10, 2012·International Immunopharmacology·Huaying WangWanjun Yu
Jan 22, 2013·Medical Oncology·Lei ZhaoRong-Yu Liu
Mar 8, 2013·Nature·Nir YosefAviv Regev
Mar 8, 2013·Nature Reviews. Cancer·A McGarry Houghton
Apr 8, 2014·Proceedings of the National Academy of Sciences of the United States of America·Seon Hee ChangChen Dong
Citations
Jan 13, 2016·International Journal of Cancer. Journal International Du Cancer·M Rita I YoungSara D Johnson
Jun 30, 2016·Expert Opinion on Therapeutic Targets·Markus JoergerSteven G Gray
Jul 19, 2017·Cold Spring Harbor Perspectives in Biology·Juming YanMichele W L Teng
Sep 8, 2016·Oncotarget·Feifei TengJinming Yu
May 7, 2019·Molecular Medicine Reports·Tingting LiaoYang Jin
Aug 3, 2017·Molecular Medicine Reports·Qiang XuYan-Mei Zhu
Jan 16, 2021·The FEBS Journal·Jöran LückeSamuel Huber
Feb 7, 2018·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Keith D EatonEffie W Petersdorf