Association between the corrected QT intervals and combined intimal-medial thickness of the carotid artery in patients with type 2 diabetes

Metabolism: Clinical and Experimental
Kohzo TakebayashiToshihiko Inukai

Abstract

The main purpose of this study was to determine whether cardiac autonomic neuropathy or coronary atherosclerosis is the more important factor affecting prolongation of the corrected QT interval (QTc) in patients with type 2 diabetes. We studied the association between QTc and the coefficient of variance of the heart rate variation (CV(RR)), which reflects cardiac autonomic neuropathy, and the combined intimal-medial thickness (IMT) of the common carotid artery, which reflects coronary atherosclerosis. In addition, we also investigated the relationship between the QTc and blood pressure, serum lipid concentrations, hemoglobin A(1C) (HbA(1C)) concentration, and duration of diabetes. We studied 75 patients with type 2 diabetes and 30 age-matched healthy individuals. The QT interval was measured in lead II of the electrocardiogram (ECG) and was corrected using Bazett's formula. Cardiac neuropathy was assessed by measuring CV(RR). Atherosclerosis was evaluated by measuring the combined IMT of the common carotid artery using B-mode ultrasonography. The QTc in patients with type 2 diabetes was significantly longer than in healthy individuals (P <.0001). The QTc more closely correlated with the IMT of the carotid artery (r = 0.7206, P ...Continue Reading

References

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Citations

Oct 30, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Daisuke MaebuchiYutaka Kiyohara
Feb 16, 2006·The American Journal of the Medical Sciences·Kohzo TakebayashiToshihiko Inukai
Feb 28, 2007·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Vanina SantiniSimona Frontoni
Mar 1, 2008·Pacing and Clinical Electrophysiology : PACE·Matthew R NelsonDavid M Herrington
Oct 16, 2007·Annals of Medicine·Damiano BaldassarreCesare R Sirtori

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