Abstract
The main purpose of this study was to determine whether cardiac autonomic neuropathy or coronary atherosclerosis is the more important factor affecting prolongation of the corrected QT interval (QTc) in patients with type 2 diabetes. We studied the association between QTc and the coefficient of variance of the heart rate variation (CV(RR)), which reflects cardiac autonomic neuropathy, and the combined intimal-medial thickness (IMT) of the common carotid artery, which reflects coronary atherosclerosis. In addition, we also investigated the relationship between the QTc and blood pressure, serum lipid concentrations, hemoglobin A(1C) (HbA(1C)) concentration, and duration of diabetes. We studied 75 patients with type 2 diabetes and 30 age-matched healthy individuals. The QT interval was measured in lead II of the electrocardiogram (ECG) and was corrected using Bazett's formula. Cardiac neuropathy was assessed by measuring CV(RR). Atherosclerosis was evaluated by measuring the combined IMT of the common carotid artery using B-mode ultrasonography. The QTc in patients with type 2 diabetes was significantly longer than in healthy individuals (P <.0001). The QTc more closely correlated with the IMT of the carotid artery (r = 0.7206, P ...Continue Reading
References
Jun 1, 1978·Circulation·P J Schwartz, S Wolf
Oct 1, 1992·Diabetes Care·R KawamoriT Kamada
Jul 1, 1992·Clinical Cardiology·T MaedaR Takaki
Jul 1, 1992·Diabetic Medicine : a Journal of the British Diabetic Association·A B HaaberT Jensen
Mar 1, 1991·Diabetologia·D J EwingB F Clarke
Nov 1, 1990·Stroke; a Journal of Cerebral Circulation·N HandaT Kamada
Jan 1, 1990·Diabetes Care·J M GoninA I Vinik
Dec 1, 1986·Circulation·P PignoliR Paoletti
Apr 1, 1987·The Journal of Clinical Endocrinology and Metabolism·J K KahnA I Vinik
Apr 1, 1995·Diabetic Medicine : a Journal of the British Diabetic Association·M VeglioP C Perin
Sep 1, 1995·Circulation·J R CrouseM G Bond
Mar 10, 1995·Cell·M E CurranM T Keating
Nov 1, 1995·Diabetes Care·S NielsenC E Mogensen
Feb 1, 1997·Nature Genetics·N NeyroudP Guicheney
Sep 1, 1997·The American Journal of Emergency Medicine·R A June, I Nasr
Feb 23, 1999·Diabetologia·M VeglioP C Perin
Aug 6, 1999·Stroke; a Journal of Cerebral Circulation·A FestaS M Haffner
Nov 14, 2000·The American Journal of Cardiology·A FestaS M Haffner
Apr 16, 2002·Journal of Internal Medicine·M VeglioP Cavallo-Perin
Citations
Oct 30, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Daisuke MaebuchiYutaka Kiyohara
Feb 10, 2006·Southern Medical Journal·Kohzo TakebayashiToshihiko Inukai
Feb 16, 2006·The American Journal of the Medical Sciences·Kohzo TakebayashiToshihiko Inukai
Sep 21, 2011·Journal of Pediatric Nursing·Shirleatha LeePedro Velasquez-Mieyer
Feb 28, 2007·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Vanina SantiniSimona Frontoni
Mar 1, 2008·Pacing and Clinical Electrophysiology : PACE·Matthew R NelsonDavid M Herrington
Apr 4, 2006·Journal of Electrocardiology·Shaojie PengXiping Xu
Nov 24, 2005·Lupus·C R L CardosoG F Salles
Nov 3, 2017·Journal of Diabetes Investigation·Shunsuke KobayashiHitoshi Sugihara
Oct 16, 2007·Annals of Medicine·Damiano BaldassarreCesare R Sirtori
Sep 22, 2021·Clinical Cardiology·Sharen LeeGary Tse