PMID: 11381188May 31, 2001Paper

Association between the endogenous retrovirus HRES-1 and multiple sclerosis in the United Kingdom--evidence of genetically different disease subsets?

Disease Markers
H B RasmussenJ Clausen

Abstract

In the present study we determined the frequencies of four haplotypes of the human T-cell lymphotropic virus-related endogenous sequence, HRES-1, in 110 multiple sclerosis (MS) patients and 100 healthy control subjects from the United Kingdom. We found evidence of an association between this endogenous retrovirus and MS (p < 0.01), in particular reflecting an increased frequency of HRES-1 haplotype 1 in the group of patients. There was no significant difference in the distribution of HRES-1 haplotypes between relapsing-remitting MS and the primary progressive form of the disease. The odds ratio for HRES-1 haplotype 1 and MS did not differ significantly between individuals positive for HLA-DR2 and DR2-negative individuals. Comparison of the observations from the present study with previous results implicated HRES-1 as a marker of genetic heterogeneity in MS.

Citations

May 1, 1995·Pharmacology & Therapeutics·A M Craig, M Malek
Aug 29, 2009·Reviews in Medical Virology·Eva BaladaMiquel Vilardell-Tarrés
Jul 15, 2018·Acta neurologica Belgica·Alia SaberiSamaneh Kazemi
Mar 15, 2003·Rheumatic Diseases Clinics of North America·Andras Perl

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