Association between the ENPP1 K121Q polymorphism and risk of diabetic kidney disease: a systematic review and meta-analysis

PloS One
Denise Alves SorticaLuis Henrique Canani

Abstract

The potential association between the K121Q (A/C, rs1044498) polymorphism in the ectonucleotide pyrophosphatase/phosphodiesterase (ENPP1) gene and risk of diabetic kidney disease (DKD) has been investigated. Nevertheless, the effect of this variant on DKD risk is still under debate, and conflicting results have been reported. To this date, no meta-analysis has evaluated the association of the K121Q polymorphism with DKD. This paper describes the first meta-analysis conducted to evaluate whether the ENPP1K121Q polymorphism is associated with DKD. A literature search was conducted to identify all case-control or cross-sectional studies that evaluated associations between the ENPP1K121Q polymorphism and DKD. Pooled odds ratios (OR) and 95% confidence intervals (95% CI) were calculated for allele contrast, additive, dominant and recessive inheritance models. Seven studies were eligible for inclusion in the meta-analysis, providing data on 3571 type 1 or type 2 diabetic patients (1606 cases with DKD and 1965 diabetic controls without this complication). No significant heterogeneity was observed among the studies included in the meta-analysis when assuming different inheritance models (I² < 50% or P > 0.10 for the entire sample and a...Continue Reading

References

Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·I R van DrielJ W Goding
Apr 29, 1998·Immunological Reviews·J W Goding, M C Howard
Feb 24, 2001·Critical Reviews in Biochemistry and Molecular Biology·M BollenC Stefan
Jun 20, 2001·American Journal of Hypertension·B M EganT L Goodfriend
Jul 31, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·L TarnowO Pedersen
Mar 27, 2002·International Journal of Epidemiology·Julian P T Higgins, David J Spiegelhalter
Jul 31, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Peter JacobsenOluf Pedersen
Feb 11, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Barry I FreedmanCarl D Langefeld
Mar 29, 2005·Diabetes·Nicola AbateViswanathan Mohan
Aug 24, 2005·International Journal of Epidemiology·Cosetta MinelliJohn Attia
Nov 10, 2005·American Journal of Physiology. Endocrinology and Metabolism·Betty A MadduxIra D Goldfine
Mar 6, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Guanjie ChenCharles Rotimi
Oct 19, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Barry I FreedmanDonald W Bowden
Nov 16, 2007·Diabetes·Jeffrey R SchellingUNKNOWN Family Investigation of Nephropathy and Diabetes Research Group
Nov 27, 2007·International Journal of Epidemiology·Cosetta MinelliJohn Attia
Jan 8, 2008·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C B LeitãoL H Canani
Apr 30, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Nedal H ArarHanna E Abboud
Sep 17, 2008·Nature Genetics·W H Linda KaoUNKNOWN Family Investigation of Nephropathy and Diabetes Research Group
Oct 28, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Salvatore De CosmoVincenzo Trischitta
Jan 6, 2009·Diabetes Care·UNKNOWN American Diabetes Association
Jun 10, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Lawrence Shih-Hsin WuEugene Lin
Jul 7, 2009·European Journal of Pharmacology·Heather H ZhouGuoqiang Jiang
Jul 23, 2009·Annals of Internal Medicine·David MoherUNKNOWN PRISMA Group
Jul 23, 2009·BMJ : British Medical Journal·David MoherUNKNOWN PRISMA Group
Jun 4, 2010·Arquivos brasileiros de endocrinologia e metabologia·Mariana P CarpenaDaisy Crispim

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