Association between the estrogen receptor beta gene and age of onset of Parkinson's disease

Psychoneuroendocrinology
Lars WestbergHans Nissbrandt

Abstract

The purpose of this study was to investigate the potential contribution of genetic variants in the estrogen receptor beta gene to the aetiology of Parkinson's disease (PD). Several lines of evidence from human and animal studies suggest a protective role for estrogen in PD. Recently the estrogen receptor beta subtype was reported to be an important mediator of estrogen actions in the nigrostriatal dopamine system. Two single nucleotide polymorphisms at position 1730 and 1082 in the ER beta gene were genotyped, using pyrosequencing, in 260 patients with PD and 308 controls recruited from the Swedish population. Neither of the two estrogen receptor beta polymorphisms was associated with an increased risk for PD. However, the G allele of the A1730G polymorphism was more frequent in patients with an early age of onset than in patients with a late age of onset of PD (P = 0.006). Patients carrying the GG genotype had an odds ratio of 2.2 for having an early onset of PD compared to non-carriers. In conclusion, our results indicate that genetic variation in the estrogen receptor beta gene may influence the age of onset of PD.

References

Mar 1, 1989·The International Journal of Neuroscience·R Sandyk
Dec 17, 1997·The Journal of Clinical Endocrinology and Metabolism·E EnmarkJ A Gustafsson
Mar 14, 1998·Bioorganicheskaia khimiia·I B MertsalovV I Tsetlin
Aug 6, 1998·The Journal of Endocrinology·D A Day, M F Tuite
Feb 18, 1999·Molecular and Cellular Endocrinology·C Y PauH G Spies
May 5, 1999·Neurology·R Saunders-PullmanS Bressman
Jun 11, 1999·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·K Isoe-WadaK Nakashima
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·L X ShenV P Stanton
Dec 15, 2000·The New England Journal of Medicine·S SveinbjörnsdottirK Stefansson
Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·L WangJ A Gustafsson
Jun 19, 2001·Neuroscience Letters·J C LambertC Lendon
Jun 20, 2001·The Journal of Comparative Neurology·P J Shughrue, I Merchenthaler
Aug 8, 2001·Parkinsonism & Related Disorders·K L TsangS L Ho
Dec 18, 2001·Movement Disorders : Official Journal of the Movement Disorder Society·M D BenedettiW A Rocca
Jan 10, 2002·European Journal of Human Genetics : EJHG·C ForsellL Lannfelt
Jan 25, 2002·American Journal of Medical Genetics·Sepideh ZareparsiHaydeh Payami
Mar 5, 2002·American Journal of Human Genetics·Yi-Ju LiMargaret A Pericak-Vance
Mar 29, 2002·American Journal of Human Genetics·Anita L DeStefanoRichard H Myers
Jul 12, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Demetrius M MaraganoreWalter A Rocca
Jul 20, 2002·Neuropharmacology·Hideyuki SawadaShun Shimohama
Sep 5, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Jian WangLong Yu
Mar 26, 2003·Psychoneuroendocrinology·U Halbreich, L S Kahn

❮ Previous
Next ❯

Citations

May 30, 2006·Journal of Clinical Pathology·Hanna GränsBirgitta Evengård
Feb 4, 2009·Journal of Neural Transmission·Olle BergmanHans Nissbrandt
Apr 28, 2010·The American Journal of the Medical Sciences·Larissa P AlcazarMaria Santos
Jan 7, 2005·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Anna HåkanssonHans Nissbrandt
May 12, 2009·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Bao ShiGuo Xiong Jin
Feb 3, 2009·Fertility and Sterility·Jin Ju KimShin Yong Moon
Nov 5, 2008·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xue-Li LiLe-Xin Wang
Jun 3, 2008·Molecular and Cellular Endocrinology·Marc MorissetteThérèse Di Paolo
Dec 8, 2007·Brain Research Reviews·M C MoraleBianca Marchetti
Mar 6, 2007·Fertility and Sterility·Gyoung Hoon LeeShin Yong Moon
Dec 16, 2006·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Anna HåkanssonHans Nissbrandt
Oct 10, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Paolo RagoneseGiovanni Savettieri
Jan 31, 2007·Annals of the New York Academy of Sciences·Paolo RagoneseGiovanni Savettieri
Oct 27, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Georgios M HadjigeorgiouAndrew Singleton
Mar 13, 2014·Frontiers in Neuroendocrinology·Glenda E GilliesZahi Qamhawi
Oct 5, 2010·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Sandeep GroverRitushree Kukreti
Jul 23, 2013·Psychoneuroendocrinology·Anna ZettergrenLars Westberg
Jul 1, 2007·Expert Review of Endocrinology & Metabolism·Silvia Carbonell SalaMaria Luisa Brandi
Sep 7, 2020·Mechanisms of Ageing and Development·Ioanna Daskalaki, Nektarios Tavernarakis
Oct 9, 2021·Essays in Biochemistry·Silvia MaioliIvan Nalvarte

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Genetics

Alzheimer's disease is a neurodegenerative disease. Discover genetic and epigenetic aspects of Alzheimer’s disease, including genetic markers and genomic structural variations with this feed.

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Related Papers

American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics
Anna HåkanssonHans Nissbrandt
Movement Disorders : Official Journal of the Movement Disorder Society
M D BenedettiW A Rocca
© 2022 Meta ULC. All rights reserved