Association between the GHR, GHRHR, and IGF1 gene polymorphisms and milk yield and quality traits in Sarda sheep

Journal of Dairy Science
M L DettoriG M Vacca

Abstract

The growth hormone receptor (GHR), the growth hormone releasing hormone receptor (GHRHR), and the insulin-like growth factor 1 (IGF1) genes are known to modulate growth, reproduction, and lactation traits in livestock. The aim of the current work was to investigate if the variation of the sheep GHR, GHRHR, and IGF1 genes is associated with milk yield and quality traits. Three hundred eighty dairy Sarda sheep were genotyped for 36 single nucleotide polymorphisms (SNP) mapping to these 3 loci, and records for milk yield and daily fat and protein yield, as well as for fat, protein, casein, lactose, and milk urea contents, pH, somatic cell score, logarithmic bacterial count, and milk energy were obtained. The linkage disequilibrium analysis was performed only for GHR, as both GHRHR and IGF1 had only 1 polymorphic SNP. Haplotype analysis revealed the existence of 7 haplotype blocks in GHR. Two haplotype blocks, including part of the intron 1 and the upstream region, were clearly separated from the remaining 5 blocks by SNP rs412986330, which may be a recombination hotspot. The latter 5 blocks were contiguous, spanning from intron 2 to exon 10. Statistical analysis revealed that the GHR polymorphism is significantly associated with m...Continue Reading

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Citations

Jul 11, 2019·The Journal of Dairy Research·Maria L DettoriGiuseppe M Vacca
Aug 8, 2020·Reproduction in Domestic Animals = Zuchthygiene·Zhanerke AkhatayevaXianyong Lan
Jul 28, 2020·Animals : an Open Access Journal From MDPI·Maria Luisa DettoriGiuseppe Massimo Vacca
Oct 21, 2020·Animals : an Open Access Journal From MDPI·Mingli WuXiuzhu Sun
Jan 12, 2021·Animal Biotechnology·Luis A Flores-EncinasJosé A Martínez-Quintana
May 15, 2021·Journal of Animal Science and Technology·Lin TaoMingxing Chu
Jun 15, 2021·Journal of Mammary Gland Biology and Neoplasia·Anna SadovnikovaRussell C Hovey
Jul 3, 2021·Animals : an Open Access Journal From MDPI·Cai ChenChengyi Song
Aug 28, 2021·Animals : an Open Access Journal From MDPI·Michele PazzolaMaria Luisa Dettori

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