Association Between the Gut Microbiota and Blood Pressure in a Population Cohort of 6953 Individuals.

Journal of the American Heart Association
Joonatan PalmuTeemu Niiranen

Abstract

Background Several small-scale animal studies have suggested that gut microbiota and blood pressure (BP) are linked. However, results from human studies remain scarce and conflicting. We wanted to elucidate the multivariable-adjusted association between gut metagenome and BP in a large, representative, well-phenotyped population sample. We performed a focused analysis to examine the previously reported inverse associations between sodium intake and Lactobacillus abundance and between Lactobacillus abundance and BP. Methods and Results We studied a population sample of 6953 Finns aged 25 to 74 years (mean age, 49.2±12.9 years; 54.9% women). The participants underwent a health examination, which included BP measurement, stool collection, and 24-hour urine sampling (N=829). Gut microbiota was analyzed using shallow shotgun metagenome sequencing. In age- and sex-adjusted models, the α (within-sample) and β (between-sample) diversities of taxonomic composition were strongly related to BP indexes (P<0.001 for most). In multivariable-adjusted models, β diversity was only associated with diastolic BP (P=0.032). However, we observed significant, mainly positive, associations between BP indexes and 45 microbial genera (P<0.05), of which ...Continue Reading

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Jul 22, 2020·Journal of the American Heart Association·Joonatan PalmuTeemu J Niiranen

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Citations

Feb 5, 2021·Cardiovascular Research·Myungsuk KimBrian J Bennett
Feb 10, 2021·International Journal of Environmental Research and Public Health·Joonatan PalmuTeemu Niiranen
Mar 10, 2021·Current Hypertension Reports·Yuichiro Yano, Teemu J Niiranen
Jun 1, 2021·Frontiers in Cardiovascular Medicine·Yang GuoBo Yu
May 26, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Arun Prasath LakshmananAnnalisa Terranegra
Jul 22, 2020·Journal of the American Heart Association·Joonatan PalmuTeemu J Niiranen
Sep 26, 2020·Journal of the American Heart Association·Joonatan PalmuTeemu J Niiranen
Jun 9, 2021·The Journal of Clinical Investigation·Soon Y TangGarret A FitzGerald
Aug 27, 2021·Metabolites·Kiera MurphyCatherine Stanton
Nov 18, 2021·The New England Journal of Medicine·David H Ellison, Paul Welling

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Methods Mentioned

BETA
urine collection

Software Mentioned

FuncTree
Vegan
SHOGUN
R package microbiome
Phyloseq
DESeq2
R packages

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