Association between the hyperuricemia and nonalcoholic fatty liver disease risk in a Chinese population: A retrospective cohort study

PloS One
Chao YangChunhong Feng

Abstract

Nonalcoholic fatty liver disease (NAFLD) is a common chronic disease associated with high levels of serum uric acid (SUA). However, whether this relationship applies in obese subjects has been unclear, and no cohort study has previously been conducted in non-obese subjects. We therefore performed a retrospective cohort study among employees of seven companies in China to investigate whether hyperuricemia was independently associated with NAFLD in obese and non-obese subjects, respectively. A total of 2383 initially NAFLD-free subjects were followed up for four years, and 15.2% (363/2383) developed NAFLD. Hyperuricemia subjects had a higher cumulative incidence than did those with normouricemia (29.0% vs. 12.9%, P<0.001). Cox proportional hazard regression analyses showed that baseline hyperuricemia was significantly associated with risk of developing NAFLD in non-obese subjects. This relationship was significantly independent of baseline age, gender, metabolic syndrome components, and other clinical variables (RR = 1.389, 95%CI: 1.051-2.099). However, this association did not exist in obese subjects (RR = 1.010, 95%CI: 0.649-1.571). The independent effect of hyperuricemia on NAFLD was stronger in females (RR = 2.138, 95%CI: 1.0...Continue Reading

References

Aug 11, 2000·Journal of Gastroenterology and Hepatology·A Lonardo, P Trande
Apr 19, 2002·The New England Journal of Medicine·Paul Angulo
May 7, 2002·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·A LonardoUNKNOWN POLI.ST.E.N.A. Study Group. Policentrica Steatosi Epatica Non Alcolica
Apr 30, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Brent A Neuschwander-Tetri, Stephen H Caldwell
Nov 14, 2003·Journal of Gastroenterology·Sei-Ichiro KojimaShohei Matsuzaki
Mar 18, 2005·Physiology·Matthias A HedigerHitoshi Endou
May 24, 2006·Rheumatic Diseases Clinics of North America·David B MountKambiz Zandi-Nejad
Dec 8, 2006·European Journal of Clinical Nutrition·A SartorioG Bedogni
Jun 15, 2007·Journal of Gastroenterology and Hepatology·Geoffrey C FarrellUNKNOWN Asia-Pacific Working Party on NAFLD
Feb 29, 2008·Journal of Hepatology·Nimantha Mark Wilfred de Alwis, Christopher Paul Day
Feb 28, 2009·Women's Health·Ayako Suzuki, Manal F Abdelmalek
Aug 21, 2009·Lancet·Pascal Richette, Thomas Bardin
Feb 23, 2010·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·P LoriaUNKNOWN NAFLD Expert Committee of the Associazione Italiana per lo studio del Fegato
Mar 12, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kausik DasAbhijit Chowdhury
Jun 22, 2010·Scandinavian Journal of Rheumatology·C-F KuoL-C See
Sep 25, 2010·Metabolism: Clinical and Experimental·Seungho RyuEliseo Guallar
Oct 1, 2010·The New England Journal of Medicine·Giovanni TargherEnzo Bonora
Jan 11, 2011·Nature Medicine·Bolormaa VandanmagsarVishwa Deep Dixit
Mar 12, 2011·Journal of Korean Medical Science·In-Cheol HwangHong-Yup Ahn
Dec 27, 2011·Journal of Pediatric Gastroenterology and Nutrition·Miriam B VosUNKNOWN NASH CRN Research Group
Nov 3, 2012·Medicine·Zobair M YounossiManirath Srishord
Feb 2, 2013·Current Opinion in Rheumatology·Changgui LiShun-Jen Chang
Mar 20, 2013·Nature Reviews. Gastroenterology & Hepatology·Quentin M AnsteeChristopher P Day
Jun 27, 2013·Climacteric : the Journal of the International Menopause Society·P J LiuY Chen
Apr 29, 2014·Biochemical and Biophysical Research Communications·Yuzhang ZhuJidong Cheng
Jun 3, 2014·Climacteric : the Journal of the International Menopause Society·P J LiuY Chen
Jun 4, 2014·The American Journal of Gastroenterology·Giacomo ZoppiniEnzo Bonora
Aug 12, 2014·Laboratory Investigation; a Journal of Technical Methods and Pathology·Yea-Jin ChoiDuk-Hee Kang
Aug 16, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mattias EkstedtRolf Hultcrantz
Dec 31, 2014·World Journal of Gastroenterology : WJG·Ren-Nan FengChang-Hao Sun
Mar 6, 2015·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Amedeo LonardoPaola Loria
Nov 7, 2015·European Journal of Gastroenterology & Hepatology·Shulan GongYangang Wang

❮ Previous
Next ❯

Citations

Aug 25, 2019·Nutrients·Marja-Riitta TaskinenJan Borén
Aug 21, 2019·Frontiers in Endocrinology·Ebe D'AdamoValerio Nobili

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.