Association between the interleukin-6 gene polymorphisms and renal cancer risk

Immunology Letters
ZhiHong LiuYiPing Lu

Abstract

Interleukin-6 (IL-6), a central proinflammatory cytokine, may be involved in the host response to cancer. We therefore aimed to evaluate the association of the IL-6 gene polymorphisms at positions -174 and -572 with predisposition to renal cancer. We conducted a hospital-based case-control study. A total of 432 subjects, including 216 pathologically-proven renal cancer cases and 216 age- and gender-matched healthy controls, were recruited in this study. Polymorphism for the IL-6 gene was genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Patients with renal cancer had a significantly higher frequency of IL-6 -174 CC genotype [odds ratio (OR)=2.08, 95% confidence interval (CI)=1.05, 4.13; P=0.04] than healthy controls. When stratifying by the grade, patients with higher grade (grade 3 or 4) renal cancer had a significantly higher frequency of IL-6 -174 CC genotype (OR=2.33, 95% CI=1.04, 5.23; P=0.04). This study is, to our knowledge, the first to examine prospectively an increased risk role of IL-6 -174 CC genotype in renal cancer susceptibility.

References

Jan 1, 1992·Cancer Immunology, Immunotherapy : CII·A S KooA Belldegrum
Mar 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Masahiro SasakiRajvir Dahiya
Aug 24, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lukas A HeflerRobert Zeillinger
Oct 4, 2005·Journal of the Society for Gynecologic Investigation·Christoph GrimmLukas A Hefler
Jan 16, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Yuichiro TanakaRajvir Dahiya
May 27, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Rohit UpadhyayBalraj Mittal
Jun 30, 2009·Cancer·Hiroshi HirataRajvir Dahiya
Feb 24, 2010·Proceedings of the National Academy of Sciences of the United States of America·Steven W ColeTeresa E Seeman
Apr 27, 2013·Lancet·Emma J CrosbieHenry C Kitchener
Nov 14, 2013·Nature Communications·Julius GudmundssonKari Stefansson
Jan 9, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal

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Citations

Aug 25, 2015·Urologic Oncology·Katarzyna KamińskaCezary Szczylik
May 20, 2016·Pathology Oncology Research : POR·Hai-Ying WangYong-Wei Li
Jul 15, 2016·Journal of Nutrition and Metabolism·Nesrine RemlaMourad Aribi
Aug 4, 2016·Genetic Testing and Molecular Biomarkers·Ayse Feyda NursalSacide Pehlivan
Nov 6, 2015·Lipids in Health and Disease·ZhiHong LiuYiPing Lu

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