Association between the major histocompatibility complex and clinical response to infliximab therapy in patients with Behçet uveitis

Japanese Journal of Ophthalmology
Kana KuroyanagiHiroshi Tsuneoka

Abstract

Our aim was to investigate whether major histocompatibility complex (MHC) polymorphisms are associated with response to infliximab therapy in Japanese patients with Behçet uveitis (BU). We retrospectively reviewed 24 patients (17 men and seven women) treated with infliximab for BU. Of them, ten patients were genotyped as HLA A*2601, and nine as HLA B*5101. Therapeutic response levels in the two groups were compared based on ocular attacks and the Behçet disease ocular attack score 24 (BOS24) over 24 months of treatment. Mean frequencies of ocular attacks at 13-18 and 19-24 months after the start of treatment were significantly higher in the HLA A*2601 group (P = 0.0392 and 0.0177, respectively). Mean BOS24-6 M values for months 1-6, 7-12, 13-18, and 19-24 were also significantly higher in the HLA A*2601 group (P = 0.0459, 0.0150, 0.0394, and 0.0178, respectively). Shortening of the infusion interval was required in eight patients in the HLA A*2601 group but in one only in the HLA B*5101 group. Behçet-disease-related adverse events occurred in eight patients in the HLA A*2601 group and two in the HLA B*5101 group. Nonocular adverse events occurred in four patients in the HLA A*2601 group and none in the HLA B*5101 group. Althoug...Continue Reading

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Citations

Nov 27, 2016·Japanese Journal of Ophthalmology·Mitsuru Sawa
Mar 25, 2018·Japanese Journal of Ophthalmology·Atsunobu TakedaKoh-Hei Sonoda
Sep 24, 2016·Current Opinion in Rheumatology·Ilknur Tugal-Tutkun
Jul 29, 2020·Frontiers in Immunology·Atsunobu TakedaKoh-Hei Sonoda
Jul 20, 2020·Current Drug Targets·Jermilia CharlesVictoria A Ploplis

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