Abstract
Our aim was to investigate whether major histocompatibility complex (MHC) polymorphisms are associated with response to infliximab therapy in Japanese patients with Behçet uveitis (BU). We retrospectively reviewed 24 patients (17 men and seven women) treated with infliximab for BU. Of them, ten patients were genotyped as HLA A*2601, and nine as HLA B*5101. Therapeutic response levels in the two groups were compared based on ocular attacks and the Behçet disease ocular attack score 24 (BOS24) over 24 months of treatment. Mean frequencies of ocular attacks at 13-18 and 19-24 months after the start of treatment were significantly higher in the HLA A*2601 group (P = 0.0392 and 0.0177, respectively). Mean BOS24-6 M values for months 1-6, 7-12, 13-18, and 19-24 were also significantly higher in the HLA A*2601 group (P = 0.0459, 0.0150, 0.0394, and 0.0178, respectively). Shortening of the infusion interval was required in eight patients in the HLA A*2601 group but in one only in the HLA B*5101 group. Behçet-disease-related adverse events occurred in eight patients in the HLA A*2601 group and two in the HLA B*5101 group. Nonocular adverse events occurred in four patients in the HLA A*2601 group and none in the HLA B*5101 group. Althoug...Continue Reading
References
Apr 1, 1985·Ophthalmology·R B NussenblattF Roberge
Aug 1, 1974·Journal of Psychosomatic Research·S Bonfils, M de M'Uzan
Sep 1, 1982·Archives of Ophthalmology·S OhnoM Aizawa
Jul 1, 1997·Tissue Antigens·N MizukiH Inoko
Feb 13, 2001·Tissue Antigens·D SayerF Christiansen
Nov 5, 2003·Cytokine·Midori MisumiYoshiaki Ishigatsubo
Apr 13, 2004·Arthritis and Rheumatism·Alfonso MartinezBenjamin Fernandez-Gutierrez
Oct 1, 2005·American Journal of Ophthalmology·Douglas A JabsUNKNOWN Standardization of Uveitis Nomenclature (SUN) Working Group
Oct 11, 2005·Immunogenetics·Yoshiki ItohHidetoshi Inoko
May 5, 2006·Tissue Antigens·Y ItohN Mizuki
Jul 14, 2010·Nature Genetics·Elaine F RemmersAhmet Gül
Jul 14, 2010·Nature Genetics·Nobuhisa MizukiHidetoshi Inoko
Jun 2, 2012·Archives of Ophthalmology·Annabelle A OkadaUNKNOWN Ocular Behçet's Disease Research Group Of Japan
Oct 24, 2012·Japanese Journal of Ophthalmology·Yuko KawazoeManabu Mochizuki
Feb 1, 2014·Japanese Journal of Ophthalmology·Toshikatsu KaburakiUNKNOWN Ocular Behçet Disease Research Group of Japan
Citations
Nov 27, 2016·Japanese Journal of Ophthalmology·Mitsuru Sawa
Mar 25, 2018·Japanese Journal of Ophthalmology·Atsunobu TakedaKoh-Hei Sonoda
Sep 24, 2016·Current Opinion in Rheumatology·Ilknur Tugal-Tutkun
Jul 29, 2020·Frontiers in Immunology·Atsunobu TakedaKoh-Hei Sonoda
Jul 20, 2020·Current Drug Targets·Jermilia CharlesVictoria A Ploplis