Association Between the NFKB1-94ins/del ATTG Polymorphism (rs28362491) and Coronary Artery Disease: A Systematic Review and Meta-Analysis

Genetic Testing and Molecular Biomarkers
Qing-Jie ChenYi-Ning Yang

Abstract

Inflammation plays an important role in the pathophysiology of coronary artery disease (CAD). NF-κB is a central regulator of inflammation. Thus the aim of this study was to conduct a systematic review and meta-analysis investigating whether the polymorphism in the NFKB1 promoter region (NFKB1-94ins(I)/del(D)ATTG, rs28362491) is associated with CAD susceptibility. PubMed, Embase, Cochrane Library and CNKI databases were searched up to 30 July 2015. All observational case-control studies that investigated the association of NFKB1 I/D polymorphism and CAD risk were included. Two reviewers independently selected the studies and extracted the data. A total of 7 studies were included in this meta-analysis. Comparison between alleles showed a 13% increased risk of CAD for D vs. I (OR = 1.13, 95% CI 1.06-1.19, PH = 0.318), and comparisons among genotypes showed a 26% increased risk of CAD for DD vs. II (OR = 1.26, 95% CI 1.12-1.43, PH = 0.125) and in the heterozygote model ID vs. II had an 11% increased risk (OR = 1.11, 95% CI 1.01-1.21, PH = 0.751). In the dominant model the risk of CAD risk was reduced by 13% (OR = 0.87, 95%CI 0.80-0.95, PH = 0.814) across the total population. Subgroup analysis by ethnicity indicated that the addit...Continue Reading

References

Jan 14, 1999·The New England Journal of Medicine·R Ross
Apr 18, 2001·American Journal of Preventive Medicine·R P HarrisUNKNOWN Methods Work Group, Third US Preventive Services Task Force
May 10, 2002·The Journal of Pharmacy and Pharmacology·Paul Bremner, Michael Heinrich
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Sep 17, 2004·Genes & Development·Matthew S Hayden, Sankar Ghosh
Nov 30, 2005·International Journal of Immunogenetics·M E A BormG Bouma
Feb 10, 2006·JAMA : the Journal of the American Medical Association·Jaime L PetersLesley Rushton
Jul 13, 2006·The Journal of Biological Chemistry·Shanjin CaoDavid M Mosser
Sep 5, 2006·Journal of Molecular and Cellular Cardiology·Gentzon HallTerry B Rogers
Oct 31, 2006·Oncogene·A HoffmannG Ghosh
Feb 17, 2007·Cardiovascular Toxicology·Allan R Brasier
Aug 19, 2007·The International Journal of Biochemistry & Cell Biology·Silvia Gaspar Pereira, Fiona Oakley
Nov 27, 2007·Journal of the American College of Cardiology·Earl S Ford, Simon Capewell
Aug 22, 2008·The Journal of Nutrition·Penny M Kris-EthertonJoan Sabaté
Jul 23, 2009·Annals of Internal Medicine·David MoherUNKNOWN PRISMA Group
Mar 23, 2010·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·V BoccardiM Barbieri
Aug 4, 2010·Annals of Internal Medicine·Gerald S Berenson, Sathanur R Srinivasan
Oct 13, 2010·Cardiology Clinics·Hayden B BosworthEugene Z Oddone
Aug 31, 2011·Human Molecular Genetics·John F Peden, Martin Farrall
Aug 17, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Peter Libby
Dec 4, 2012·Nature Genetics·Panos DeloukasNilesh J Samani

❮ Previous
Next ❯

Citations

Aug 28, 2020·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Tanima ChatterjeeMaitree Bhattacharyya

❮ Previous
Next ❯

Methods Mentioned

BETA
Genotyping

Software Mentioned

STATA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Clinical and Experimental Medicine
Junli FanJianmin Chen
Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Changxi ZhouChangting Liu
Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Jian Hui WuYong Xu
© 2022 Meta ULC. All rights reserved