Association between the oxytocin receptor gene polymorphism (rs53576) and bulimia nervosa

European Eating Disorders Review : the Journal of the Eating Disorders Association
Youl-Ri KimJanet Treasure

Abstract

Oxytocin circuits are implicated in the regulation of appetite and weight. Variants in the oxytocin receptor (OXTR) gene have been associated with bulimic behaviour. This study aimed to investigate the association between the OXTR gene and eating disorders. We genotyped six single nucleotide polymorphisms, rs53576, rs237879, rs2228485, rs13316193, rs2254298 and rs1042778, located within the OXTR gene in Korean patients with eating disorders using the single-base extension method. We studied a total of 262 women, including 69 patients with anorexia nervosa, 90 patients with bulimia nervosa (BN), and 103 healthy women. We found a positive association between the G allele of OXTR rs53576 and BN. In the BN group, the G carriers showed a high score on the behavioural inhibition system. These findings suggest the involvement of the oxytocinergic system in the mechanism that underlies BN.

References

Aug 1, 1979·Psychological Medicine·G Russell
Feb 23, 1999·Advances in Experimental Medicine and Biology·F MoosP Richard
Dec 10, 1999·Human Molecular Genetics·J L HolderA R Zinn
May 17, 2000·Biological Psychiatry·W H KayeC W McConaha
Jun 1, 1961·Archives of General Psychiatry·A T BECKJ ERBAUGH
Sep 10, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Janet A AmicoLinda Rinaman
Jan 5, 2007·Personality and Social Psychology Review : an Official Journal of the Society for Personality and Social Psychology, Inc·Luke D SmillieChris J Jackson
Feb 3, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Anthony SclafaniJanet A Amico
Jun 29, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J A MiedlarJ A Amico
Sep 18, 2007·Nature Genetics·Anna L DixonWilliam O C Cookson
May 3, 2008·Molecular Endocrinology·Bassil M KublaouiAndrew R Zinn
Jun 4, 2008·Neuroreport·Yuki TakayanagiKatsuhiko Nishimori
Jul 19, 2008·PLoS Computational Biology·Enrico RossoniFrançoise Moos
Jul 29, 2008·Progress in Brain Research·Gareth LengYuki Takayanagi
Nov 21, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yi-Chun Loraine TungGiles S H Yeo
Apr 21, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Michael J LuchtDieter Rosskopf
Nov 26, 2009·Proceedings of the National Academy of Sciences of the United States of America·Sarina M RodriguesDacher Keltner
Jan 6, 2010·Harvard Review of Psychiatry·Kai Macdonald, Tina Marie Macdonald
Mar 30, 2010·Neuron·Richard P EbsteinAriel Knafo
Jul 22, 2010·Proceedings of the National Academy of Sciences of the United States of America·Heike TostAndreas Meyer-Lindenberg
Aug 21, 2010·Proceedings of the National Academy of Sciences of the United States of America·Heejung S KimShelley E Taylor
Nov 3, 2010·Progress in Molecular Biology and Translational Science·Anke HinneyJohannes Hebebrand
Jun 8, 2011·Psychiatry Research·Amy HarrisonLuke D Smillie
Aug 20, 2011·Nature Reviews. Neuroscience·Andreas Meyer-LindenbergMarkus Heinrichs
Sep 8, 2011·Proceedings of the National Academy of Sciences of the United States of America·Shimon Saphire-BernsteinShelley E Taylor
Oct 8, 2011·PloS One·Nicolas DeblonFrançoise Rohner-Jeanrenaud
Nov 16, 2011·Proceedings of the National Academy of Sciences of the United States of America·Aleksandr KoganSarina Rodrigues Saturn
Jun 1, 2012·Obesity Facts·John R W MenziesGareth Leng
Jul 18, 2012·Nature·Deniz AtasoyScott M Sternson
Jul 20, 2012·Nordic Journal of Psychiatry·Michael J LuchtDieter Rosskopf
Aug 9, 2012·The Journal of Clinical Endocrinology and Metabolism·Elizabeth A LawsonAnne Klibanski
Aug 23, 2012·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Vesna BoraskaEleftheria Zeggini
Mar 23, 2013·Frontiers in Endocrinology·Nancy SabatierJohn Menzies

❮ Previous
Next ❯

Citations

Jun 23, 2015·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Kristen M CulbertKelly L Klump
Nov 3, 2015·Body Image·Stuart B MurrayJonathan M Mond
May 27, 2017·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Michael Lutter
Aug 7, 2019·European Eating Disorders Review : the Journal of the Eating Disorders Association·Katarzyna KucharskaMałgorzata Bednarska-Makaruk
Jul 25, 2019·Current Opinion in Psychiatry·Janet Treasure, Laura Eid
Nov 20, 2016·European Eating Disorders Review : the Journal of the Eating Disorders Association·Nadia MicaliElizabeth A Lawson
Sep 5, 2018·Current Psychiatry Reports·Franziska PlessowElizabeth A Lawson
Sep 30, 2017·Nature Reviews. Endocrinology·Elizabeth A Lawson
Jul 15, 2021·Journal of Eating Disorders·Victoria BurmesterMarta Crous-Bou

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.