Abstract
Pancreas transplantation is considered a therapeutic option for patients with complicated diabetes mellitus. In this study, we compared survival rate between patients on the waiting list for pancreas transplant alone(PTA), simultaneous pancreas-kidney(SPK) transplant, and pancreas after kidney(PAK) transplant and transplant recipients. A total of 503 patients (PTA:n = 116; SPK:n = 303; PAK:n = 84) and 280 PT recipients (PTA:n = 89; SPK:n = 155; PAK:n = 36) were retrospectively analyzed at our center between February 2000 and December 2015; 11.9%(60/503) of the patients on the waiting list and 4.3%(12/280) of the PT recipients died. The overall survival rate was higher in the waiting list group for the first year (99.3% vs. 97.8%), after which it was significantly higher in PT group (p = 0.039). The overall relative risk of all-cause mortality for transplant recipients was 2.145(p = 0.285) for PTA, 0.688(p = 0.735) for PAK, however,0.361 (p = 0.012) for SPK compared with that for the waiting list patients. SPK transplant recipients had considerable higher survival benefits, despite the relatively long waiting period, especially after 1 year. In addition, PTA and PAK can also be considered as a treatment option as patient surviva...Continue Reading
References
Dec 2, 1999·The New England Journal of Medicine·R A WolfeF K Port
Dec 6, 2003·JAMA : the Journal of the American Medical Association·Jeffrey M VenstromDavid M Harlan
Dec 4, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Rainer W G GruessnerAngelika C Gruessner
Aug 5, 2009·Journal of Hepato-biliary-pancreatic Sciences·Jason F ReynosoRainer W G Gruessner
Jan 22, 2011·Gut and Liver·Duck Jong Han, David Er Sutherland
May 9, 2012·Transplantation Proceedings·J B ParkD J Han
Mar 21, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·David van DellenAfshin Tavakoli
Jan 30, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R KandaswamyB L Kasiske
Jan 13, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R KandaswamyB L Kasiske
Feb 3, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J Y ChoiD J Han
Apr 21, 2016·Current Opinion in Organ Transplantation·Robert J StrattaRainer W G Gruessner
May 28, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R J StrattaR W G Gruessner
Citations
Jul 12, 2018·Transplantation·Sandesh ParajuliDidier Mandelbrot
Feb 23, 2019·PloS One·Cristian Rodelo-HaadPedro Aljama
Jul 10, 2020·Journal of Clinical Medicine·Taihei ItoToshinori Ito
Aug 28, 2020·Scandinavian Journal of Immunology·Bergithe E Oftedal, Anette S B Wolff
Apr 30, 2019·Transplantation
May 17, 2021·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Aleksandra KuklaMichael R Rickels