Association between the polymorphisms in exon 12 of hypoxia-inducible factor-1alpha and the clinicopathological features of oral squamous cell carcinoma

Oral Oncology
Tzong-Ming ShiehChung-Ji Liu

Abstract

Oral squamous cell carcinoma (OSCC) is a common malignancy. The incidence of OSCC is particularly high in some Asian countries because of the popularity of the habit of chewing areca. Hypoxia-inducible factor-1alpha (HIF-1alpha) is up-regulated in the hypoxic microenvironment to enhance tumor survival. Five polymorphisms have been identified in exon 12 of HIF-1alpha including the C1772T polymorphism causing P582S, and the G1790A polymorphism causing A588T of the HIF-1alpha protein. This study investigated the relationship between these functional polymorphisms and the risk of progression of OSCC. PCR and direct sequencing were utilized to compare the genotypic polymorphism and allelic frequency of HIF-1alpha in 96 normal controls and 305 OSCC patients. No statistically significant difference in C1772T and G1790A genotypes and allelic frequency between control and OSCC patients was found. However, multivariate analysis indicated that the A carrier of HIF-1alpha G1790A in OSCC patients was significantly higher in larger tumors than in the contrasting group with an adjusted odds ratio of 2.92. The T carrier of HIF-1alpha C1772T in buccal cancer patients was significantly higher in the non-areca-chewing group with an adjusted odds ...Continue Reading

References

Feb 1, 1971·The Journal of Experimental Medicine·J FolkmanG Williams
Jun 6, 1995·Proceedings of the National Academy of Sciences of the United States of America·G L WangG L Semenza
Nov 1, 1995·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Y C KoC C Tsai
May 30, 2001·Current Opinion in Genetics & Development·P H MaxwellP J Ratcliffe
Apr 26, 2005·International Journal of Cancer. Journal International Du Cancer·Jean-Philippe DalesColette Charpin
Mar 16, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·J M A PijnenborgP G Groothuis
Aug 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tzong-Ming ShiehKuo-Wei Chang
Feb 9, 2008·Cell Death and Differentiation·A Weidemann, R S Johnson

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Citations

Sep 21, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xin HuChao You
Aug 19, 2015·Chemico-biological Interactions·Jing LiXuejun Jin
Apr 21, 2018·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Jitender PrasadAnju Chauhan
Jul 17, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xin HuChao You
Jan 16, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Gang WuPei-Chun Sun
Feb 11, 2015·World Journal of Gastroenterology : WJG·Xiao SunMeng Li
Sep 22, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Shaleen Multani, Dhananjaya Saranath

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