Association between the PPP3CC gene, coding for the calcineurin gamma catalytic subunit, and bipolar disorder.

Behavioral and Brain Functions : BBF
Flavie MathieuE T Tzavara

Abstract

Calcineurin is a neuron-enriched phosphatase that regulates synaptic plasticity and neuronal adaptation. Activation of calcineurin, overall, antagonizes the effects of the cyclic AMP activated protein/kinase A. Thus, kinase/phosphatase dynamic balance seems to be critical for transition to long-term cellular responses in neurons, and disruption of this equilibrium should induce behavioral impairments in animal models. Genetic animal models, as well as post-mortem studies in humans have implicated calcineurin dependent calcium and cyclic AMP regulated phosphorylation/dephosphorylation in both affective responses and psychosis. Recently, genetic association between schizophrenia and genetic variation of the human calcineurin A gamma subunit gene (PPP3CC) has been reported. Based on the assumption of the common underlying genetic factor in schizophrenia and bipolar affective disorder (BPAD), we performed association analysis of CC33 and CCS3 polymorphisms of the PPP3CC gene reported to be associated with schizophrenia in a French sample of 115 BPAD patients and 97 healthy controls. Carrying 'CT' or 'TT' genotypes of the PPP3CC-CC33 polymorphism increased risk to develop BPAD comparing to carry 'CC' genotype (OR = 1.8 [1.01-3.0]; p...Continue Reading

References

Oct 1, 1988·Theoretical Population Biology·R C Lewontin, M W Feldman
Nov 20, 2002·Journal of Neurochemistry·Outi KontkanenEero Castrén
Jul 10, 2003·Proceedings of the National Academy of Sciences of the United States of America·Tsuyoshi MiyakawaSusumu Tonegawa
Jul 10, 2003·Proceedings of the National Academy of Sciences of the United States of America·David J GerberSusumu Tonegawa
Aug 5, 2003·Nature Reviews. Genetics·Jeffrey D Wall, Jonathan K Pritchard
Nov 6, 2003·Science's STKE : Signal Transduction Knowledge Environment·Husseini K ManjiTodd D Gould
Apr 2, 2005·Nature Reviews. Neuroscience·Zhengui Xia, Daniel R Storm

❮ Previous
Next ❯

Citations

May 26, 2012·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Marie-Hélène DizierFlavie Mathieu
Mar 1, 2012·Journal of Affective Disorders·Amelia L GallitanoBarbara Geller
Nov 19, 2015·Revista colombiana de psiquiatría·Diana Patricia Restrepo, Alejandra Tamayo
Mar 7, 2013·Journal of Psychiatric Research·Hans-Gert BernsteinBernhard Bogerts
May 27, 2016·Journal of Neurotrauma·Nicole D OsierC Edward Dixon
Dec 8, 2017·Journal of Molecular Neuroscience : MN·Alma Genis-MendozaSandra Morales-Mulia
Feb 10, 2011·Pharmacological Reviews·Jean-Martin Beaulieu, Raul R Gainetdinov
Mar 9, 2021·Neurogenetics·Nele CosemansHilde Peeters
Apr 4, 2021·International Journal of Molecular Sciences·Tomasz BoczekLudmila Zylinska

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic

Software Mentioned

EH
plus

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.