Association between the Pro12Ala variant of the peroxisome proliferator-activated receptor-gamma2 gene and increased 24-h diastolic blood pressure in obese patients with type II diabetes

Journal of Human Hypertension
A StefańskiK Pilarska

Abstract

The aim of the study was to examine an association between the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor (PPAR)-gamma2 gene and blood pressure values assessed by 24-h ambulatory blood pressure monitoring (ABPM) in obese patients with long-lasting type II diabetes. Two hundred and fourteen obese patients (95 men and 119 women) with above 10-year history of type II diabetes were recruited for the study. In all the patients, ABPM was performed and other parameters, including age, body mass index (BMI), waist/hip ratio (WHR), haemoglobin A1c (HbA(1c)), serum lipids and creatinine were also evaluated. The Pro12Ala polymorphism was analysed by polymerase chain reaction-restriction fragment length polymorphism. Two subgroups of patients were compared: (a) Pro/Pro: homozygotic Pro/Pro (n=154) and (b) Ala: Ala allele carriers (Ala/Ala+Ala/Pro) (n=60). The studied groups were not different when age, BMI, WHR, HbA(1c), lipids, creatinine and frequency of hypertension were compared. A similar ratio of patients from both groups were treated with angiotensin-converting enzyme inhibitors, calcium channel blockers, diuretics, beta-blockers and alpha-blockers. A difference was observed in a mean 24-h (Ala: 71.9+/-8...Continue Reading

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Citations

Dec 25, 2008·Nature Clinical Practice. Nephrology·Yolanda E Bogaert, Stuart Linas
Aug 10, 2007·Journal of Human Hypertension·J ChackathayilB Cheung
Oct 26, 2007·Journal of Human Hypertension·V J KarthikeyanR J MacFadyen
Apr 25, 2009·PPAR Research·Weimin He
Jul 14, 2014·Seminars in Nephrology·Colleen Flynn
Oct 31, 2008·Diabetic Medicine : a Journal of the British Diabetic Association·M MontagnanaO Melander
Oct 1, 2014·Journal of Cellular and Molecular Medicine·Qing LiJiang Hong
Jul 22, 2008·Neurobiology of Aging·Nancy A WestHal Morgenstern
Sep 5, 2008·Journal of Diabetes and Its Complications·Katherine A PratteJohn E Hokanson
Jan 31, 2008·American Journal of Physiology. Endocrinology and Metabolism·Niru GoenkaJ Paul O'Hare
Feb 25, 2020·Journal of Immunology Research·Bogna Grygiel-GórniakNatalia Rozwadowska

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