Association between the rs1143634 polymorphism in interleukin-1B and chronic periodontitis: Results from a meta-analysis composed by 54 case/control studies

Gene
Felipe Rodolfo Pereira da SilvaDaniel Fernando Pereira Vasconcelos

Abstract

Several factors are involved in the periodontitis with host response through cytokines and as well as with influence of polymorphisms in cytokine genes, however the results remained contradictory. This study aimed at evaluating the rs1143634 polymorphism in interleukin-1B gene, a cytokine gene, and the risk of chronic periodontitis with conducting a meta-analysis focusing in ethnicity. A review in literature was performed in several databases to studies published before June 2017. Data extraction was performed by two calibrated investigators and the calculations of the meta-analysis were obtained through Review Manager version 5.2 statistical software with Odds Ratio (OR) calculation and Funnel plot (P < 0.05) to heterogeneity and the Comprehensive Meta-analysis version 3.3.070 to assessment publication bias by Egger's and Begg's tests. In overall, 54 case/control studies composed the meta-analysis. T allele was significantly associated with patients case (OR = 1.35, 95% CI: 1.24, 1.48, P < 0.00001) in the overall analysis. The stratified evaluation showed the rs1143634 polymorphism had significant association with disease in Caucasian, Asian and mixed population was excepted in African ethnicity (P > 0.05). No publication bias...Continue Reading

Citations

Jul 22, 2019·Archivum Immunologiae Et Therapiae Experimentalis·Aniela BrodzikowskaJan Kowalski
Feb 23, 2020·BMC Oral Health·Felipe Rodolfo Pereira da SilvaJosé Fernando Marques Barcellos
Feb 14, 2019·International Journal of Dentistry·Petra Borilova LinhartovaLydie Izakovicova Holla
Jan 5, 2020·International Journal of Oral Science·Ran ChengTao Hu
Dec 10, 2020·Journal of Periodontal Research·Juliana Gomes GalenoDaniel Fernando Pereira Vasconcelos
Nov 24, 2020·Cytokine·Felipe Rodolfo Pereira da SilvaAnna Carolina Toledo da Cunha Pereira
Dec 18, 2020·Journal of Clinical Medicine·Małgorzata KozakAndrzej Pawlik
Feb 16, 2021·Oral Diseases·Lucas E S OliveiraJefferson S Oliveira
Nov 5, 2020·Cytokine·Nidhi MedaraNeil M O'Brien-Simpson
Jul 25, 2021·European Journal of Dentistry·Muhammad Mansoor MajeedRafat Amin

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