Association between the rs4753426 polymorphism in MTNR1B with fasting plasma glucose level and pancreatic β-cell function in gestational diabetes mellitus

Genetics and Molecular Research : GMR
Ying ZhanS G Liu

Abstract

We investigated the association between rs4753426 single nucleotide polymorphisms in the melatonin receptor 1B (MTNR1B) gene and the risk of developing gestational diabetes mellitus (GDM). A total of 516 gravidas (186 with GDM and 330 non-diabetic controls) were enrolled in the study. Genotype and allele frequencies of rs4753426 in the MTNR1B gene were detected by DNA sequencing. Fasting plasma glucose and fasting insulin levels were measured to calculate the homeostasis model assessment for insulin resistance (HOMA-IR) and for β-cell function. Three genotypes (CC, CT, and TT) were found in both groups. The frequencies of CC, CT, and TT genotypes for the GDM group were 70.97, 22.58, and 6.45% vs 53.03, 39.70, and 7.27% in the control group, respectively. Significant differences were observed in genotype frequencies between groups (P < 0.05). T and C allele frequencies in the GDM group were 17.74 and 82.26%, respectively, and in the control group were 27.12 and 72.88%, respectively. Significant differences in T and C allele frequencies were found between groups (P < 0.05). In the GDM group, the C allele was associated with increased fasting plasma glucose level and reduced pancreatic β-cell function (P < 0.05). There were no sig...Continue Reading

Citations

Sep 15, 2018·Endocrine Reviews·José Cipolla-Neto, Fernanda Gaspar do Amaral
Jun 14, 2019·Expert Review of Endocrinology & Metabolism·Fernanda Gaspar Do AmaralJosé Cipolla-Neto
Aug 19, 2017·Cellular and Molecular Life Sciences : CMLS·Daniel P Cardinali, Daniel E Vigo
Aug 28, 2018·International Journal of Endocrinology·Eduardo Spinedi, Daniel P Cardinali
Aug 13, 2021·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Wenwen WeiHongsong Yu

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