Association between the STK15 F31I polymorphism and cancer susceptibility: a meta-analysis involving 43,626 subjects

PloS One
Weifeng TangHaiyong Gu

Abstract

The association between the Serine/threonine kinase 15 (STK15) F31I polymorphism (rs2273535) and cancer susceptibility remains controversial. To further investigate this potential relationship, we conducted a comprehensive meta-analysis of 27 published studies involving a total of 19,267 multiple cancer cases and 24,359 controls. Our results indicate statistical evidence of an association between the STK15 F31I polymorphism and the increased risk of overall cancer in four genetic models: AA vs. TA+TT, AA vs. TT, AA vs. TA, and A vs. T. In a stratified analysis by cancer type, there was an increased risk of breast cancer in four genetic models: AA vs. TA+TT, AA vs. TT, AA vs. TA, and A vs. T, as well as esophageal cancer in two genetic models: AA vs. TA+TT and AA vs. TA. In a stratified analysis by ethnicity, there was a significant increase in cancer risk among Asians, but not Caucasians, in four genetic models: AA vs. TA+TT, AA vs. TT, AA vs. TA and A vs. T. In addition, a stratified analysis by ethnicity in the breast cancer subgroup revealed a significant increase in cancer risk among Asians in two genetic models: AA vs. TA+TT and AA vs. TT, as well as among Caucasians in one genetic model: AA vs. TA. In summary, this meta-a...Continue Reading

References

Apr 10, 1997·Nature·C LengauerB Vogelstein
Jan 1, 1999·Nature·C LengauerB Vogelstein
Jul 27, 2002·Science·Richard S Maser, Ronald A DePinho
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Jul 24, 2004·Carcinogenesis·Kathleen M EganHiroki Nagase
Jul 24, 2004·Carcinogenesis·Tong SunDongxin Lin
Jan 5, 2005·Nature Reviews. Cancer·Tomotoshi MarumotoHideyuki Saya
Feb 3, 2005·International Journal of Cancer. Journal International Du Cancer·Yen-Li LoChen-Yang Shen
Jul 29, 2005·International Journal of Cancer. Journal International Du Cancer·Tuija HienonenLauri A Aaltonen
Jan 18, 2006·Cancer Causes & Control : CCC·David G CoxDavid J Hunter
Jan 21, 2006·International Journal of Cancer. Journal International Du Cancer·Paul D TerryJack A Taylor
Jun 10, 2006·Cancer Letters·Sandrine TchatchouBarbara Burwinkel
Jul 20, 2006·Journal of the National Cancer Institute·Olivia FletcherJulian Peto
Nov 23, 2006·Cancer Letters·Linda VidarsdottirJorunn E Eyfjord
Feb 20, 2007·Cancer Research·Paraskevi BriassouliSpiros Linardopoulos
May 17, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jinyun ChenMarsha L Frazier
Oct 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Wei WangXifeng Wu
May 5, 2009·Neoplasia : an International Journal for Oncology Research·Yoshifumi BabaShuji Ogino
Jul 23, 2009·Annals of Internal Medicine·David MoherUNKNOWN PRISMA Group
Jul 23, 2009·BMJ : British Medical Journal·David MoherUNKNOWN PRISMA Group
Aug 13, 2009·Breast Cancer Research and Treatment·UNKNOWN MARIE-GENICA Consortium on Genetic Susceptibility for Menopausal Hormone Therapy Related Breast Cancer Risk
Feb 9, 2011·World Neurosurgery·Kapila S Navaratne, Robert J Weil
Oct 13, 2011·World Journal of Gastroenterology : WJG·Ilyar SheyhidinHua Wang
Nov 2, 2012·Human Genetics·Sabine SiegertMichael Krawczak
Jun 25, 2013·Journal of Cancer Survivorship : Research and Practice·Guixiang ZhaoLina S Balluz
Jul 5, 2013·International Journal of Cancer. Journal International Du Cancer·Mathilde TouvierPaule Latino-Martel

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Citations

Aug 30, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Xu-Guang GuoYong Xia
Dec 3, 2014·Experimental and Therapeutic Medicine·Jianfei LuoLi Zou
Aug 27, 2014·Molecular Genetics and Genomics : MGG·Jun QinHui-Qiang Si
Jun 9, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Chao HuangCungang Wu
Mar 2, 2016·Asian Pacific Journal of Cancer Prevention : APJCP·Eric Tzyy Jiann ChongPing-Chin Lee
Feb 12, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Xiang-Zhen KongJing Yu
May 28, 2019·Trends in Genetics : TIG·Johnny R RamroopAmanda Ewart Toland

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Methods Mentioned

BETA
genotyping

Software Mentioned

STATA

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