Association between the timing of surgery for complicated, left-sided infective endocarditis and survival

American Heart Journal
Andrew WangICE-PLUS Investigators

Abstract

In patients with active infective endocarditis (IE), the relationship between timing of surgery and survival is uncertain. The objective was to evaluate clinical characteristics associated with timing of surgery and the association between surgical timing and 6-month survival in complicated, left-sided IE. In a prospective, multicenter, observational registry (The International Collaboration on Endocarditis-PLUS, registry from 2008 to 2012), clinical factors associated with timing of surgery during the index hospitalization were determined among 485 adult patients with definite, complicated, left-sided IE who underwent cardiac surgery during their index hospitalization. The relationship between early surgical intervention (<7 days from admission to surgery center) and outcome after surgery was analyzed. The primary end point of the study was 6-month survival. The median time to surgery from admission to surgical center was 7 (interquartile range 2-15) days. Patients who underwent earlier surgery were more likely transferred to the surgical center (74.2% vs 46.4%, P < .001) and had a lower percentage of preexisting heart failure (before IE diagnosis) (6.0% vs 17.3%, P < .001) but higher rate of acute heart failure (53.2% vs 38.4...Continue Reading

References

Apr 19, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J S LiG R Corey
Dec 25, 2003·JAMA : the Journal of the American Medical Association·Holenarasipur R VikramVincent J Quagliarello
Mar 24, 2004·Circulation·Vivian H ChuAndrew Wang
Jun 24, 2005·JAMA : the Journal of the American Medical Association·Vance G FowlerUNKNOWN ICE Investigators
Mar 11, 2009·Archives of Internal Medicine·David R MurdochUNKNOWN International Collaboration on Endocarditis-Prospective Cohort Study (ICE-PCS) Investigators
Feb 18, 2010·Circulation·Tahaniyat LalaniUNKNOWN International Collaboration on Endocarditis-Prospective Cohort Study (ICE-PCS) Investigators
Jun 16, 2010·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Z A KanafaniD J Sexton
Jul 20, 2010·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·N Fernández-HidalgoA Pahissa
Dec 21, 2010·The Journal of Thoracic and Cardiovascular Surgery·Jeffrey G GacaPeter K Smith
Nov 24, 2011·JAMA : the Journal of the American Medical Association·Todd KieferAndrew Wang
Jun 29, 2012·The New England Journal of Medicine·Duk-Hyun KangDae-Won Sohn
May 8, 2013·Circulation·Emilio García-CabreraUNKNOWN Spanish Network for Research in Infectious Diseases
Jul 17, 2013·JAMA Internal Medicine·Tahaniyat LalaniUNKNOWN International Collaboration on Endocarditis–Prospective Cohort Study Investigators
Sep 17, 2015·Circulation·Larry M BaddourUNKNOWN American Heart Association Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease of the Council on Cardiovascular
Jan 21, 2017·Journal of the American College of Cardiology·Thomas J CahillBernard D Prendergast

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Citations

Jan 8, 2021·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Marco RipaUNKNOWN Ospedale San Raffaele Endocarditis Team
Mar 12, 2021·Frontiers in Medicine·Guillermo CuervoJordi Carratalà
Mar 13, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Efthymia GiannitsiotiUNKNOWN Hellenic Society of Chemotherapy

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