Association between the ulcerative colitis endoscopic index of severity (UCEIS) and outcomes in acute severe ulcerative colitis

Journal of Crohn's & Colitis
Crispin CorteSimon Travis

Abstract

The Ulcerative Colitis Endoscopic Index of Severity (UCEIS) accounts for 86% of the variance between observers in the overall assessment of endoscopic severity, but has not been correlated with outcomes. Consecutive cases of acute severe colitis (ASC) defined by Truelove and Witts (TW) criteria were retrospectively evaluated. Demographic details, number of TW criteria, prior medical therapy, UCEIS and inpatient medical therapy were recorded. Pre-specified (adverse) endpoints included rescue therapy, colectomy and readmission. Eighty-nine patients, 48 (54%) male, mean age 38 years, all received intravenous hydrocortisone 400mg/d (median 5 days [range 1-11]). Median follow-up was 14 months (2-33). Forty-eight (54%) were diagnosed the year prior to or at the time of admission. Thirty-six (40%) required rescue therapy (infliximab 25/36, ciclosporin 12/36, one receiving both). Twenty-one (24%) underwent colectomy on the index admission (9/21) or during follow-up (12/21). Median UCEIS score (possible range 0-8) was 5 (3-8). UCEIS was higher in patients requiring rescue therapy or colectomy (median score 6 [range 4-8] versus 5/8 [3-8], both p < 0.005). For UCEIS ≥5, 27/54 (50%) required rescue therapy, compared with 9/33 (27%) for UCE...Continue Reading

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Citations

Jan 14, 2016·Current Gastroenterology Reports·Britt Christensen, David T Rubin
Jul 28, 2015·Journal of Gastroenterology and Hepatology·Crispin J Corte, Rupert W Leong
Dec 10, 2015·Current Gastroenterology Reports·Shara Nguyen KetSimon Travis
Mar 26, 2016·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Jordina LlaóEugeni Domènech
Jun 5, 2015·Journal of Crohn's & Colitis·Simon TravisSatish Keshav
May 27, 2016·Alimentary Pharmacology & Therapeutics·J-H ChenUNKNOWN IBD Sydney Organisation and the Australian Inflammatory Bowel Diseases Consensus Working Group
Oct 26, 2016·Nature Reviews. Gastroenterology & Hepatology·Pieter HindryckxGeert D'Haens
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Dec 22, 2017·Journal of Gastroenterology and Hepatology·Matthew C ChoyPeter De Cruz
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