Association between Thr21Met and Ser89Asn polymorphisms of the urotensin-II (UTS2) gene, diabetes mellitus, and diabetic retinopathy

Current Eye Research
Seydi OkumuşAbdullah T Demiryurek

Abstract

To evaluate possible role of the UTS2 gene polymorphisms (Thr21Met and Ser89Asn) in the genetic susceptibility to diabetic retinopathy (DR) in a Turkish population. Total number of 280 patients with DR (nonproliferative DR 170 and proliferative DR 110), 291 nondiabetic healthy controls, and 113 diabetic controls (without DR) were included to this study. The detection of UTS2 gene polymorphisms was achieved with PCR-RFLP technique. The Discovery Studio 2.1 program was used for molecular modeling analysis. Thr21Met (T21M) and Ser89Asn (S89N) polymorphisms of the UTS2 gene were associated with the risk of developing diabetes and DR. M21M genotype frequencies were high in PDR (8.9% in diabetic control vs. 54.6% in PDR, P = 0.0092) group. Increases in 21M allele frequency (52.7% in diabetic control vs. 76.4% in PDR, P < 0.0001) frequency in PDR group were detected. However, there were no changes in genotype and allele frequencies for T21M in NPDR group. There were decreases in the S89N genotype (23.9% in diabetic control vs. 13.5%) and 89N allele frequencies (11.9% in diabetic control vs. 6.8%) in NPDR group. However, S89S genotype (76.1% in diabetic control vs. 86.4%) and 89S allele frequencies (88.1% in diabetic control vs. 93.2%)...Continue Reading

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Citations

Jan 22, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Onder YumrutasAhmet Arslan
Dec 13, 2016·Postgraduate Medical Journal·Jing ZhaoWen-Hui Ding
Apr 24, 2018·Acta Ophthalmologica·Suzanne BroadgateVictor Chong
Nov 25, 2018·Hormones : International Journal of Endocrinology and Metabolism·Mehmet CalanFırat Bayraktar
Feb 20, 2021·Immunological Investigations·Asmaa KamalOla El Sisi

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