Association Between Thyroid-Stimulating Hormone and Renal Function: a Mendelian Randomization Study

Kidney & Blood Pressure Research
Chi ChenYingli Lu

Abstract

Increasing evidence suggests an association between thyroid-stimulating hormone (TSH) and estimated glomerular filtration rate (eGFR). We conducted a Mendelian randomization (MR) analysis to examine the causality of the association between TSH and eGFR. 10,603 participants were recruited from the Survey on Prevalence in East China for Metabolic Diseases and Risk Factors (SPECT-China), which was performed in 23 sites in East China during 2014-2016. We constructed weighted genetic risk scores (GRS) for TSH based on three TSH-related single nucleotide polymorphisms. eGFR was calculated using the CKD Epidemiology Collaboration formula. The instrumental variable (IV) was used to explore the causal relationship between TSH and eGFR. Higher measured TSH levels were associated with lower eGFR (B -0.717, 95%CI -0.958, -0.476) after multivariable adjustment. However, by MR analysis, per SD increase in the TSH_GRS was significantly associated with TSH (B 0.155, 95%CI 0.076, 0.235, P< 0.001) but not with eGFR (B -0.127, 95%CI -0.364, 0.110). Using IV estimator, no causal associations were observed for genetically instrumented TSH with eGFR. By a genetic approach that limits residual confounding and reverse causation in observational conven...Continue Reading

Citations

Sep 11, 2019·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Yijian ZhangBin Pi
Apr 10, 2020·The Journal of Clinical Endocrinology and Metabolism·Aleksander KuśMarco Medici
Jan 23, 2020·Thyroid : Official Journal of the American Thyroid Association·Marek SaracynGrzegorz Kamiński
Jan 9, 2020·Thyroid : Official Journal of the American Thyroid Association·Christina EllervikDaniel I Chasman
Apr 28, 2020·Journal of Diabetes Research·Yi ChenYingli Lu

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