Association between thyrotropin levels and insulin sensitivity in euthyroid obese adolescents

Thyroid : Official Journal of the American Thyroid Association
Asma JavedSeema Kumar

Abstract

Thyrotropin (TSH) levels display a positive association with body mass index (BMI), and the prevalence of isolated hyperthyrotropinemia is higher in obese adolescents compared to their normal weight controls. However, the metabolic significance of the higher TSH in obese adolescents is less clear. The objective of this study was to determine the relationship between TSH concentrations and insulin sensitivity, lipids, and adipokines in euthyroid, non-diabetic, obese adolescents. Thirty-six euthyroid, non-diabetic, obese adolescents between the ages of 12 and 18 years underwent a 75 g oral glucose tolerance test. Insulin sensitivity (Si) and pancreatic β-cell function as assessed by disposition index (DI) were measured using the oral glucose minimal model approach. Cholesterol (total, low-density lipoprotein [LDL-C], and high-density lipoprotein [HDL-C]), triglycerides (TG), interleukin-6 (IL-6), total and high molecular weight (HMW) adiponectin, and retinol binding protein-4 (RBP4) were also determined. Associations between measures of thyroid function and Si, DI, lipids, and adipokines were computed using Pearson's correlation coefficient and multiple regression analysis. The mean age of the subjects was 14.3±1.88 years, and th...Continue Reading

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Citations

Nov 4, 2016·Nature Reviews. Endocrinology·Mariacarolina SalernoFilippo De Luca
Sep 8, 2016·Thyroid : Official Journal of the American Thyroid Association·Trang N LeEdmond P Wickham
Jun 7, 2019·Childhood Obesity·Aris GiannakopoulosChristina Kanaka-Gantenbein
Sep 16, 2021·Hormone Molecular Biology and Clinical Investigation·Niranjan GopalAshok Kumar Ahirwar

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Methods Mentioned

BETA
Assay
enzyme-linked immunosorbent assays

Clinical Trials Mentioned

NCT00858247

Software Mentioned

IR

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