Association between TLR4 (+896A/G and +1196C/T) polymorphisms and gastric cancer risk: an updated meta-analysis

PloS One
Quan ZhouLiping Su

Abstract

Toll-like receptor 4 (TLR4) is a receptor of lipopolysaccharide in the signaling transduction of gastric epithelial cell. It plays a pivotal role in activation of innate immunity and pathogen recognition and thus acts as a modulator in the development and progression of gastric cancer. Growing studies explored the association of polymorphisms in TLR4 with susceptibility to gastric cancer, but the results have remained controversial and conflicting. To investigate the effect of two selected TLR4 (+896A/G and +1196C/T) polymorphisms on gastric cancer, we performed a meta-analysis. A comprehensive search was conducted to identify all eligible case-control publications investigating the association between TLR4 polymorphisms and gastric cancer risk. Odds ratios (OR) and corresponding 95% confidence intervals (CI) were used to assess such association. Up to March 26 2014, 10 published case-control studies from PubMed and EMBase were available, involving a total of 1888 gastric cancer patients and 3433 control subjects. In the overall meta-analyses, a significantly increased gastric cancer risk was detected in TLR4 +896A/G polymorphism (heterozygous model, AG vs. AA: OR = 1.67, 95% CI, 1.39-2.01; additive model, G vs. A: OR = 1.64, 9...Continue Reading

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Citations

Jul 16, 2015·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Haifeng HouZheng Sun
Mar 23, 2017·World Journal of Gastroenterology : WJG·Magdalena ChmielaPaweł Stączek
Mar 7, 2019·Frontiers in Immunology·Sabine Groeger, Joerg Meyle
Jul 23, 2020·Current Pharmaceutical Design·Arunaksharan NarayanankuttyJoice T Job

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