Association between tonsillitis and newly diagnosed ankylosing spondylitis: A nationwide, population-based, case-control study

PloS One
Wen-Cheng ChaoHsin-Hua Chen

Abstract

To investigate the association between tonsillitis and the risk of newly diagnosed ankylosing spondylitis (AS). We used 2003-2012 data from Taiwan's National Health Insurance Research Database to conduct this nationwide, population-based, case-control study. We identified AS patients newly diagnosed between 2005 to 2012 as the study group and selected age, sex and index-year matched (1:6) non-AS individuals as controls. The association between tonsillitis and risk of newly diagnosed AS was determined by calculating odds ratios (ORs) with 95% confidence intervals (CIs) using conditional logistic regression analysis. We identified 37,002 newly diagnosed AS cases and 222,012 matched non-AS controls. Patients with AS were more likely to have tonsillitis (aOR 1.46, 95% CI 1.43-1.50), appendicitis (aOR 1.29, 95% CI 1.13-1.48) and periodontitis (aOR 1.35, 95% CI 1.31-1.38) than non-AS control subjects. The association between tonsillitis and AS was consistent using varying definitions for tonsillitis, and we further found that a high frequency of visits for tonsillitis, a high medical cost for tonsillitis and a long interval between diagnosis were associated with newly diagnosed AS in a dose-response manner. Furthermore, the associati...Continue Reading

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