Association between topical beta-blockers and risks of cardiovascular and respiratory disease in patients with glaucoma: a retrospective cohort study

BMJ Open
Hsin-Yi ChenChia-Hung Kao

Abstract

To determine if topical beta-blocker use is associated with increased risks of cardiovascular and respiratory diseases in patients with glaucoma. A retrospective cohort analysis was conducted using the database from Taiwan's National Health Insurance programme. In total, 12 336 newly diagnosed patients with glaucoma from January 2000 to December 2010 were included. The patients with glaucoma were subdivided into two cohorts according to whether they used topical beta-blockers or combination drugs (BBCDs). The study endpoints included pneumonia, acute respiratory failure, stroke and coronary artery disease (CAD). Univariable and multivariable Cox proportional hazards regression models were used to estimate HRs and 95% CIs for the endpoints of both cohorts. The BBCD cohort had a slightly higher risk of acute respiratory failure (adjusted HRs=1.16, 95% CI 1.00 to 1.34) and lower risk of CAD (aHR=0.93, 95% CI 0.87 to 0.99) than the non-BBCD cohort. Additionally, the risk of stroke was significantly higher in BBCD cohort than in the non-BBCD cohort (aHR=1.39, 95% CI 1.23 to 1.58), especially the ischaemic stroke (aHR=1.44, 95% CI 1.26 to 1.64; aHR=1.44, 98.75% CI 1.21 to 1.71). After considering the multiplicative interaction of age...Continue Reading

References

May 25, 2002·Journal of the American Geriatrics Society·Gary D NovackD William Molloy
Jan 17, 2003·Health Affairs·Robert E Hurley, Stephen A Somers
Nov 19, 2003·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Michelle HoudeJacques LeLorier
Feb 21, 2006·The British Journal of Ophthalmology·H A Quigley, A T Broman
Mar 12, 2008·Archives of Ophthalmology·Suh-Yuh WuUNKNOWN Barbados Eye Studies Group
Sep 20, 2008·Ophthalmology·Rogier P H M MüskensNomdo M Jansonius
Jul 11, 2014·Journal of Ophthalmology·Sevda Aydin KurnaOsman Okan Olcaysu
Sep 11, 2014·Journal of Ophthalmology·Hsin-Yi ChenWen-Chi Chen
Jan 15, 2015·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Doreen SchmidlAlina Popa-Cherecheanu
Jul 21, 2015·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Hsin-Yi ChenChia-Hung Kao
Aug 4, 2015·Respiratory Medicine Case Reports·Hetain PatelJorge Guerrero
Sep 9, 2015·Case Reports in Critical Care·Muhammad Asim RanaWaleed Tharwat Aletreby
Jun 23, 2018·Journal of Translational Medicine·Lee-Won ChongYi-Chao Hsu

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