Association Between Transient Opioid Use and Short-Term Respiratory Exacerbation Among Adults With Chronic Obstructive Pulmonary Disease: A Case-Crossover Study

American Journal of Epidemiology
Yiran RongSujith Ramachandran

Abstract

The association of historical opioid use with health care use and death among patients with chronic obstructive pulmonary disease (COPD) has been tested. Using Mississippi Medicaid data, we examined the association of transient or short-term opioid use and acute respiratory exacerbations among adults with COPD. We used a case-crossover design and 2013-2017 Mississippi Medicaid administrative claims data. A total of 1,972 qualifying exacerbation events occurred in 1,354 beneficiaries. The frequency and dose of opioid exposure in the 7 days before the exacerbation were examined and compared with the opioid exposure in 10 control windows, each 7 days long, before the exacerbation. Adjusted odds ratios were estimated using conditional logistic regression models to estimate the risk of opioid use on exacerbations after accounting for use of bronchodilators, corticosteroids, benzodiazepines, and β-blockers. Overall, opioid exposure in the 7 days before an exacerbation was significantly associated with acute respiratory exacerbation (odds ratio = 1.81; 95% confidence interval: 1.60, 2.05). Each 25-mg increase in morphine equivalent daily dose was associated with an 11.2% increase in the odds of an acute respiratory exacerbation (odds ...Continue Reading

References

May 29, 1998·American Journal of Respiratory and Critical Care Medicine·T A SeemungalJ A Wedzicha
Oct 18, 2005·American Journal of Surgery·Shiv TaylorRobert A Kozol
Sep 4, 2007·Lancet·Jadwiga A Wedzicha, Terence A R Seemungal
May 6, 2008·British Journal of Anaesthesia·K T S Pattinson
Nov 26, 2008·Joint Commission Journal on Quality and Patient Safety·Adit A GindeCarlos A Camargo
Jun 26, 2009·International Journal of Chronic Obstructive Pulmonary Disease·Terence A R SeemungalJadwiga A Wedzicha
Feb 18, 2012·American Journal of Respiratory and Critical Care Medicine·Mark B ParshallUNKNOWN American Thoracic Society Committee on Dyspnea
Jul 28, 2012·The European Respiratory Journal·Jadwiga A WedzichaTerence A R Seemungal
Dec 6, 2012·Anadolu Kardiyoloji Dergisi : AKD = the Anatolian Journal of Cardiology·UNKNOWN Editors of Heart Group journals
Jan 22, 2013·The American Journal of Nursing·Leah Burt, Susan Corbridge
Dec 12, 2013·Drugs·David C CurrowAmy P Abernethy
Feb 1, 2014·BMJ : British Medical Journal·Magnus P EkströmDavid C Currow
Apr 24, 2014·International Journal of Epidemiology·Murray A Mittleman, Elizabeth Mostofsky
Sep 7, 2014·Expert Review of Respiratory Medicine·Nicholas T Vozoris
Sep 24, 2014·BMJ : British Medical Journal·Shawn D Aaron
Dec 9, 2014·JAMA Internal Medicine·Jean-Pascal FournierSamy Suissa
Mar 25, 2015·Annals of the American Thoracic Society·Magnus EkströmDavid C Currow
Nov 27, 2015·British Journal of Clinical Pharmacology·David C CurrowMiriam J Johnson
Mar 16, 2016·JAMA : the Journal of the American Medical Association·Deborah DowellRoger Chou
Jun 22, 2016·Respirology : Official Journal of the Asian Pacific Society of Respirology·Ana Rodrigo-TroyanoOriol Sibila
Jul 16, 2016·The European Respiratory Journal·Nicholas T VozorisPaula A Rochon
Mar 10, 2017·The European Respiratory Journal·Magnus EkströmMiriam J Johnson
Aug 11, 2017·European Respiratory Review : an Official Journal of the European Respiratory Society·Salvatore CorraoFrancesco Perticone
Oct 25, 2017·International Journal of Chronic Obstructive Pulmonary Disease·David Mg HalpinBartolomé Celli
Nov 10, 2017·Current Opinion in Anaesthesiology·Kapil GuptaFrances F Chung

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