Association between tumor necrosis factor-α and chronic obstructive pulmonary disease: a systematic review and meta-analysis

Therapeutic Advances in Respiratory Disease
Yang YaoShengyu Wang

Abstract

Patients diagnosed with chronic obstructive pulmonary disease (COPD) have increased risks for a series of physical and mental illnesses. Tumor necrosis factor-α (TNF-α) has been reported to participate in the development of COPD and its complications. However, the values of blood TNF-α level used in the diagnosis of COPD remains controversial. In view of this, we performed a systematic review and meta-analysis to evaluate the correlation between TNF-α level and COPD. We searched PubMed, Web of Science, Embase and CNKI up to May 2018. The selection criteria were set according to the PICOS framework. A random-effects model was then applied to evaluate the overall effect sizes by calculating standard mean difference (SMD) and its 95% confidence intervals (CIs). A total of 40 articles containing 4189 COPD patients and 1676 healthy controls were included in this meta-analysis. The results indicated a significant increase in TNF-α level in the COPD group compared with the control group (SMD: 1.24, 95% CI: 0.78-1.71, p < 0.00001). According to the subgroup analyses, we noted that TNF-α level was associated with predicted first second of forced expiration (FEV1) (%) and study region. However, no association between TNF-α level and COPD...Continue Reading

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May 21, 2020·American Journal of Physiology. Cell Physiology·Tayyab RehmanMichael J Welsh
Nov 5, 2020·Fundamental & Clinical Pharmacology·Andrew Higham, Dave Singh
Nov 24, 2020·International Journal of Chronic Obstructive Pulmonary Disease·Juliana Souza UzelotoErcy Mara Cipulo Ramos
Feb 19, 2021·Pulmonary Pharmacology & Therapeutics·Min ChenDong Wu
Sep 4, 2021·Biologics : Targets & Therapy·Mario CazzolaMaria Gabriella Matera
Jul 6, 2021·Physiology International·M FeketeJ T Varga
Nov 17, 2021·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Aditi ShahNajib Ayas

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