Association between two CHRNA3 variants and susceptibility of lung cancer: a meta-analysis

Scientific Reports
Xiao QuJiajun Du

Abstract

Genome-wide association studies (GWAS) have identified two CHRNA3 polymorphisms (rs578776 and rs938682) associated with lung cancer risk. Furthermore, these polymorphisms were investigated and genotyped by PCR analysis. All eligible case-control studies published up to Mar 1st 2015 were identified by searching Pubmed and Embase database. Negative association between rs578776-T allele and risk of lung cancer was obtained without obvious heterogeneity (OR: 0.83, 95% CI: 0.79-0.86; p = 0.898 for Q test). Rs938682-C allele carriers had a 12% to 28% decreased risk. Genotype model analysis showed results of dominant model for rs578776 (OR with 95% CI: 0.839(0.718-0.981)), dominant model for rs938682 (OR with 95% CI: 0.778(0.663-0.912)) and homozygous model for rs938682 (OR with 95% CI: 0.767(0.708-0.831)) were statistically significant. Subgroup analysis indicated rs578776-T variant had protective effect in Smokers, Caucasians, two histology subgroups, and two match subgroups. Meanwhile, rs938682-C allele was associated with decreased risk in Smokers, Caucasians, Lung cancer, and two match subgroups. Meta-regression suggested ethnicity might be the major source of heterogeneity in allele model and homozygous model for rs938682. Moreo...Continue Reading

References

Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Jan 15, 2003·The Journal of School Health·UNKNOWN Office on Smoking and Health, Division of Adolescent and School Health National Center for Chronic Disease Prevention and He
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
May 27, 1950·Journal of the American Medical Association·E L WYNDER, E A GRAHAM
Oct 19, 2004·Seminars in Cancer Biology·Gerald N WoganLawrence A Loeb
Oct 30, 2008·Journal of the National Cancer Institute·Margaret R SpitzXifeng Wu
May 16, 2009·Human Molecular Genetics·Jen C WangUNKNOWN COGEND collaborators and GELCC collaborators
Jun 19, 2009·Clinical Pharmacology and Therapeutics·H Wipfli, J M Samet
Jul 23, 2009·BMJ : British Medical Journal·David MoherUNKNOWN PRISMA Group
Jun 18, 2010·Journal of the National Cancer Institute·Christopher I AmosMargaret R Spitz
Jul 1, 2010·Human Molecular Genetics·Helen M HansenJohn K Wiencke
Jul 21, 2010·Proceedings of the National Academy of Sciences of the United States of America·L Elliot HongElliot A Stein
Nov 13, 2010·Advances in Cancer Research·Jun YokotaTakashi Kohno
Jan 14, 2011·Cancer Causes & Control : CCC·Lori C SakodaChu Chen
Aug 4, 2011·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Michael S Conlon, Mary A Bewick
Aug 25, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Maria N TimofeevaPaul Brennan
Sep 1, 2011·Nature Reviews. Genetics·Zuben E Sauna, Chava Kimchi-Sarfaty
Aug 18, 2012·Human Molecular Genetics·Maria N TimofeevaUNKNOWN Transdisciplinary Research in Cancer of the Lung (TRICL) Research Team
Sep 27, 2012·International Journal of Cancer. Journal International Du Cancer·Xavier TekpliShanbeh Zienolddiny
Feb 12, 2013·Translational Oncology·Zhijun LiYongjun Zhang
Sep 26, 2013·Frontiers in Physiology·Ma Reina ImprogoPaul D Gardner
Sep 26, 2013·Frontiers in Psychiatry·Jason D RobinsonPaul M Cinciripini
Nov 5, 2013·Genetic Epidemiology·Sarah H StephensMarissa A Ehringer
Jan 9, 2014·Molecular Cancer Research : MCR·Courtney Schaal, Srikumar P Chellappan
Apr 2, 2014·International Journal of Molecular Sciences·Ping HeJian-Xing He
Aug 21, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·S Lani ParkLoïc Le Marchand
Feb 7, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Wenjing ZhouChao Chen
Apr 1, 2010·Research Synthesis Methods·Michael BorensteinHannah R Rothstein

❮ Previous
Next ❯

Citations

Nov 1, 2016·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Leah S Richmond-RakerdIan R Gizer
Oct 11, 2019·Molecular Genetics & Genomic Medicine·Mariana R SilvaFernanda de Toledo Gonçalves
Mar 5, 2020·The Cochrane Database of Systematic Reviews·Marcela Cortés-JofréXavier Bonfill Cosp
Apr 5, 2018·Frontiers in Public Health·Mohammed A I Al-ObaideAbdel-Salam G Abdel-Salam
Feb 20, 2019·Parkinsonism & Related Disorders·Yu-Hsuan ChuangBeate Ritz

❮ Previous
Next ❯

Software Mentioned

STATA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.