Abstract
Previous epidemiological studies have evaluated the association between the ABCB1 polymorphism and the risk of breast cancer with conflicting results. Hence, we conducted a meta-analysis of the ABCB1 gene and risk of breast cancer to obtain the most reliable estimate of the association. PubMed, Embase, and Web of Science databases were searched. A total of eight studies including 3,829 cases and 6,193 controls were identified. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were extracted and pooled to assess the strength of associations between the ABCB1 C3435T and rs2214102 G>A polymorphisms and risk of breast cancer. Of these studies, only one deviated from Hardy-Weinberg equilibrium. Summary estimates indicated that the ABCB1 C3435T polymorphism was not associated with increased risk of breast cancer in the allele contrast model (T vs. C, pooled OR = 1.15; 95% CI = 0.89-1.48); the co-dominant model (CT vs. CC, OR = 1.12 [0.86-1.46] and TT vs. CC, OR = 1.30 [0.79-2.15]); the dominant model (OR = 0.80 [0.63-1.02]; and the recessive model (OR = 0.83 [0.57-1.22]). In the sensitivity analysis by ethnicity, no statistically significant associations were detected in Asians. However, in Caucasian women the T allele cont...Continue Reading
References
Jul 13, 2000·The New England Journal of Medicine·P LichtensteinK Hemminki
Aug 10, 2001·Drug Discovery Today·U BrinkmannM Eichelbaum
Mar 27, 2002·The Pharmacogenomics Journal·U Brinkmann, M Eichelbaum
Apr 3, 2004·European Journal of Haematology·Krzysztof JamroziakTadeusz Robak
Sep 12, 2006·International Journal of Cancer. Journal International Du Cancer·Milena SantFranco Berrino
Nov 23, 2006·Cancer·Guillermo GervasiniJulio Benitez
Feb 16, 2007·Pharmacogenetics and Genomics·Silje H NordgardVessela N Kristensen
Jun 15, 2007·Archives of Medical Research·Sebahat TurgutGünfer Turgut
Oct 19, 2007·Cancer Research·Zuben E SaunaMichael M Gottesman
May 29, 2008·JAMA : the Journal of the American Medical Association·Linda M DongUlrike Peters
Apr 25, 2009·DNA and Cell Biology·Farnoosh TatariJavad Behravan
May 29, 2009·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Aug 8, 2009·Clinical Breast Cancer·Joseph GeorgeElangovan Sunder
Aug 13, 2009·Breast Cancer Research and Treatment·UNKNOWN MARIE-GENICA Consortium on Genetic Susceptibility for Menopausal Hormone Therapy Related Breast Cancer Risk
Sep 16, 2009·The Pharmacogenomics Journal·M CizmarikovaA Mirossay
Nov 4, 2009·Oncology Reports·L A Henríquez-HernándezL Fernández Pérez
Jan 19, 2010·Genetics and Molecular Research : GMR·M TaheriR Omranipour
Citations
Dec 2, 2010·Breast Cancer Research and Treatment·Jun WangJingwang Bi
Mar 30, 2011·Breast Cancer Research and Treatment·Sihua PengMaode Lai
Jan 3, 2013·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·T HeL Liu
Mar 8, 2012·PloS One·Daniele CampaFederico Canzian
Jun 6, 2014·PloS One·Lijun JingBrian Z Ring
May 31, 2011·Pharmacogenomics·Bruno Stieger, Peter J Meier
May 20, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Weirong YaoYingliang Li
Aug 23, 2012·Breast Cancer Research and Treatment·Khyber Saify, Mostafa Saadat
Feb 15, 2013·Pharmacological Reports : PR·Błażej RubiśMaria Rybczyńska
Dec 25, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Houshiyar GhafouriAbdolhakim Hoseini
Dec 1, 2012·Toxicology Mechanisms and Methods·Gül ÖzhanBuket Alpertunga
Nov 30, 2011·Drug Metabolism and Pharmacokinetics·Ichiro Ieiri
Sep 28, 2013·Gene·Zhaoming WangJianmin Bian
Nov 14, 2013·PloS One·Miao Han, Yun Zheng
Jun 14, 2013·PloS One·Qian XuYuan Yuan
Sep 17, 2013·PloS One·Ping-Yu WangShu-Yang Xie
Dec 12, 2012·PloS One·Kshitij Srivastava, Anvesha Srivastava
Dec 14, 2012·PloS One·Man-Tang QiuLin Xu
Nov 3, 2012·PloS One·Danni ShiChangjun Yin
Sep 2, 2016·BMC Genetics·Amal TazziteSellama Nadifi
Jan 1, 2015·PloS One·Fatma M SheblJill Koshiol
Feb 4, 2016·Asian Pacific Journal of Cancer Prevention : APJCP·Ali M AbuhaliemaKhalil Z Al Majdalawi
Feb 9, 2012·Molecular Biology Reports·Xiaojing ShengZhengdong Zhang
Jul 28, 2020·Molecular Biology Reports·Soodabeh ShahidSalesAmir Avan