Association between two polymorphisms of ABCB1 and breast cancer risk in the current studies: a meta-analysis

Breast Cancer Research and Treatment
Pei-Hua LuMin-Bin Chen

Abstract

Previous epidemiological studies have evaluated the association between the ABCB1 polymorphism and the risk of breast cancer with conflicting results. Hence, we conducted a meta-analysis of the ABCB1 gene and risk of breast cancer to obtain the most reliable estimate of the association. PubMed, Embase, and Web of Science databases were searched. A total of eight studies including 3,829 cases and 6,193 controls were identified. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were extracted and pooled to assess the strength of associations between the ABCB1 C3435T and rs2214102 G>A polymorphisms and risk of breast cancer. Of these studies, only one deviated from Hardy-Weinberg equilibrium. Summary estimates indicated that the ABCB1 C3435T polymorphism was not associated with increased risk of breast cancer in the allele contrast model (T vs. C, pooled OR = 1.15; 95% CI = 0.89-1.48); the co-dominant model (CT vs. CC, OR = 1.12 [0.86-1.46] and TT vs. CC, OR = 1.30 [0.79-2.15]); the dominant model (OR = 0.80 [0.63-1.02]; and the recessive model (OR = 0.83 [0.57-1.22]). In the sensitivity analysis by ethnicity, no statistically significant associations were detected in Asians. However, in Caucasian women the T allele cont...Continue Reading

References

Mar 27, 2002·The Pharmacogenomics Journal·U Brinkmann, M Eichelbaum
Sep 12, 2006·International Journal of Cancer. Journal International Du Cancer·Milena SantFranco Berrino
Feb 16, 2007·Pharmacogenetics and Genomics·Silje H NordgardVessela N Kristensen
Jun 15, 2007·Archives of Medical Research·Sebahat TurgutGünfer Turgut
Oct 19, 2007·Cancer Research·Zuben E SaunaMichael M Gottesman
May 29, 2008·JAMA : the Journal of the American Medical Association·Linda M DongUlrike Peters
May 29, 2009·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Aug 13, 2009·Breast Cancer Research and Treatment·UNKNOWN MARIE-GENICA Consortium on Genetic Susceptibility for Menopausal Hormone Therapy Related Breast Cancer Risk
Sep 16, 2009·The Pharmacogenomics Journal·M CizmarikovaA Mirossay
Nov 4, 2009·Oncology Reports·L A Henríquez-HernándezL Fernández Pérez
Jan 19, 2010·Genetics and Molecular Research : GMR·M TaheriR Omranipour

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Citations

Dec 2, 2010·Breast Cancer Research and Treatment·Jun WangJingwang Bi
Jan 3, 2013·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·T HeL Liu
May 31, 2011·Pharmacogenomics·Bruno Stieger, Peter J Meier
May 20, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Weirong YaoYingliang Li
Aug 23, 2012·Breast Cancer Research and Treatment·Khyber Saify, Mostafa Saadat
Feb 15, 2013·Pharmacological Reports : PR·Błażej RubiśMaria Rybczyńska
Dec 25, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Houshiyar GhafouriAbdolhakim Hoseini
Feb 4, 2016·Asian Pacific Journal of Cancer Prevention : APJCP·Ali M AbuhaliemaKhalil Z Al Majdalawi
Feb 9, 2012·Molecular Biology Reports·Xiaojing ShengZhengdong Zhang

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