Association between type 2 diabetes and prenatal exposure to the Ukraine famine of 1932-33: a retrospective cohort study

The Lancet. Diabetes & Endocrinology
L H LumeyA M Vaĭserman

Abstract

The effect of fetal and early childhood living conditions on adult health has long been debated, but empirical assessment in human beings remains a challenge. We used data from during the man-made Ukrainian famine of 1932-33 to examine the association between restricted nutrition in early gestation and type 2 diabetes in offspring in later life. We included all patients with type 2 diabetes diagnosed at age 40 years or older in the Ukraine national diabetes register 2000-08, and used all individuals born between 1930 and 1938 from the 2001 Ukraine national census as the reference population. This study population includes individuals born before and after the famine period as controls, and those from regions that experienced extreme, severe, or no famine. We used prevalence odds ratios (ORs) as the measure of association between type 2 diabetes and early famine exposure, with stratification by region, date of birth, and sex for comparisons of diabetes prevalence in specific subgroups. Using these two datasets, we compared the odds of type 2 diabetes by date and region of birth in 43,150 patients with diabetes and 1,421,024 individuals born between 1930 and 1938. With adjustment for season of birth, the OR for developing type 2 ...Continue Reading

References

Jan 30, 2003·Population Studies·Jacques VallinSerhii Pyrozhkov
May 29, 2004·International Journal of Epidemiology·Aryeh D SteinL H Lumey
Oct 28, 2005·The New England Journal of Medicine·Matthew W Gillman
Apr 17, 2008·Cancer Causes & Control : CCC·D TrichopoulosH O Adami
Jul 30, 2008·Molecular and Cellular Endocrinology·R Huw Jones, Susan E Ozanne
Oct 29, 2008·Proceedings of the National Academy of Sciences of the United States of America·Bastiaan T HeijmansL H Lumey
Oct 26, 2010·Endocrine Reviews·Z HochbergK Albertsson-Wikland
Jan 12, 2011·Annual Review of Public Health·L H LumeyEzra Susser
Mar 7, 2013·Cellular and Molecular Life Sciences : CMLS·Ionel SandoviciMiguel Constância
Mar 15, 2013·Proceedings of the National Academy of Sciences of the United States of America·Stefan ThurnerDavid C Kasper
Sep 3, 2014·Acta Obstetricia Et Gynecologica Scandinavica·Allan VaagLouise G Grunnet

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Citations

Feb 18, 2016·Diabetology & Metabolic Syndrome·Mykolay KhalangotVictor Kravchenko
Feb 3, 2016·Social Science & Medicine·Thomas A Glass, Usama Bilal
Sep 8, 2015·The Lancet. Diabetes & Endocrinology·Matthew W Gillman
Jun 18, 2016·Nature Reviews. Endocrinology·Romain Barrès, Juleen R Zierath
Oct 26, 2016·International Journal of Cancer. Journal International Du Cancer·Shao-Hua Xie, Jesper Lagergren
Nov 3, 2016·The Journal of Nutrition·Jing WangMeian He
Nov 22, 2017·International Journal of Epidemiology·Ruogu MengUNKNOWN China Kadoorie Biobank Collaborative Group
Jun 8, 2018·Circulation. Genomic and Precision Medicine·Daniela ZanettiErik Ingelsson
Dec 24, 2018·Endocrine Reviews·Manuel H Aguiar-Oliveira, Andrzej Bartke
Apr 19, 2019·JPEN. Journal of Parenteral and Enteral Nutrition·Michael SkinnerPeter F Nichol
Aug 25, 2019·BJOG : an International Journal of Obstetrics and Gynaecology·H ZhangK Tang
Dec 4, 2019·Nature Reviews. Endocrinology·Chihua LiL H Lumey
Mar 29, 2020·International Journal of Environmental Research and Public Health·Yan ZhangAiling Liu
Feb 13, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Khemayanto HidayatLi-Qiang Qin
Sep 9, 2019·BMJ Open·Sarah Gonzalez-NahmSara E Benjamin-Neelon
Jun 10, 2020·Experimental Biology and Medicine·Mykola KhalangotAlexander Vaiserman
Aug 28, 2019·Diabetologia·Denise S Fernandez-TwinnRichard Saffery
Aug 28, 2019·Diabetologia·Aryeh D SteinChittaranjan S Yajnik
Oct 27, 2017·Global Challenges·Mustapha U Imam, Maznah Ismail
Jul 29, 2017·Epigenetics & Chromatin·Alexander M VaisermanRandy L Jirtle
Jul 12, 2018·Current Diabetes Reports·Usama BilalAna V Diez-Roux
Oct 13, 2018·Nature Reviews. Endocrinology·Paul ZimmetLinong Ji
Mar 23, 2019·Nature Reviews. Endocrinology·Chihua LiL H Lumey
Dec 1, 2019·Nature Reviews. Endocrinology·Chihua LiL H Lumey
Jul 6, 2018·Current Diabetes Reports·Unjali P GujralK M Venkat Narayan
Apr 5, 2019·International Journal of Genomics·Alexander Vaiserman, Oleh Lushchak
Apr 11, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Jonathan C K Wells
May 17, 2019·American Journal of Epidemiology·Rita HamadFrances A Tylavsky
Apr 3, 2020·Journal of the American Heart Association·Rui DuUNKNOWN REACTION Study Group ‡

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