Association between uric acid and pulse wave velocity in hypertensive patients and in the general population: a systematic review and meta-analysis

Blood Pressure
Paola ReboraAlessandro Maloberti

Abstract

Purpose: The association between serum uric acid (SUA) and pulse wave velocity (PWV), has been extensively evaluated but with some discrepancies in results. A further limitation refers to the fact that only few data were analyzed taking into account the possible effects of gender. The purpose of this study was to estimate the association between SUA and arterial stiffness in general population and hypertensive patients, as a whole population and as divided by gender, by pooling results from existing studies.Materials and methods: Carotid-femoral and brachial-ankle PWV (cf- and ba-PWV) have been analyzed separately and subgroup analyses by gender are reported. Among 692 potentially relevant works, 24 articles were analyzed.Results: Seven studies referred to cf-PWV in the general population with an overall positive association at adjusted analysis for both males and females (beta regression coefficient (ß): 0.07; 95%CI: 0.03; 0.11 and ß: 0.06; 95%CI: 0.03; 0.09, respectively). Twelve studies referred to ba-PWV in the general population with the finding of a positive association at adjusted analysis for females (ß: 0.04; 95% confidence interval (CI): 0.01;0.07), but not for males (ß: 0.13; 95%CI: -0.09; 0.34). In hypertensive pati...Continue Reading

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Citations

Oct 22, 2020·Archives of Endocrinology and Metabolism·Charanpreet SinghSavita Kumari
Jun 25, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Anxin WangYongjun Wang
Aug 31, 2021·Clinical and Experimental Hypertension : CHE·Lanfranco D'EliaFerruccio Galletti

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