Association between urinary 3-phenoxybenzoic acid and body mass index in Korean adults: 1(st) Korean National Environmental Health Survey

Annals of Occupational and Environmental Medicine
Minsang YooYun-Chul Hong

Abstract

According to US-EPA report, the use of pyrethrins and pyrethroids has increased during the past decade, and their area of use included not only in agricultural settings, but in commerce, and individual household. It is known that urinary 3-PBA, major metabolite of pyrethroid, have some associations with health effect in nervous and endocrine system, however, there's no known evidence that urinary 3-PBA have associations with obesity. We used data of 3671 participants aged above 19 from the Korean National Environmental Health Survey in 2009-2011. In our analysis, multivariate piece-wise regression and logistic regression analysis were used to investigate the association between urinary 3-PBA (3-Phenoxybenzoic Acid) and BMI. Log-transformed level of urinary 3-PBA had significantly positive association with BMI at the low-level range of exposure (p < 0.0001), and opposite associations were observed at the high level exposure (p = 0.04) after adjusting covariates. In piece-wise regression analysis, the flexion point that changes direction of the associations was at around 4 ug/g creatinine of urinary 3-PBA. As quintiles based on concentration of urinary 3-PBA increased to Q4, the ORs for prevalence of overweight (BMI ≥ 23 kg/m(2))...Continue Reading

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Citations

Mar 10, 2018·Environmental Health : a Global Access Science Source·S ParvezP D Winchester
Jul 30, 2020·The Biochemical Journal·Robert M GutgesellAlison C Holloway
Aug 29, 2020·International Journal of Environmental Research and Public Health·Arin A BalalianRobin Whyatt
Oct 8, 2020·Journal of Exposure Science & Environmental Epidemiology·Jin Hee KimYun-Chul Hong
May 18, 2020·The Science of the Total Environment·Fucai DengLizhong Zhu
Nov 6, 2021·Environmental Science and Pollution Research International·Hai Duc NguyenMin-Sun Kim

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