Association between use of disease-modifying antirheumatic drugs and diabetes in patients with ankylosing spondylitis, rheumatoid arthritis, or psoriasis/psoriatic arthritis: a nationwide, population-based cohort study of 84,989 patients

Therapeutics and Clinical Risk Management
Hsin-Hua ChenChing-Heng Lin

Abstract

The aim of this study is to investigate the association between the use of disease-modifying antirheumatic drugs (DMARDs) and diabetes mellitus (DM) in patients with ankylosing spondylitis (AS), rheumatoid arthritis (RA), or psoriasis/psoriatic arthritis (PS/PSA). This retrospective cohort study used a nationwide, population-based administrative database to enroll 84,989 cases with AS, RA, or PS/PSA who initiated treatment with anti-tumor necrosis factor (anti-TNF) drugs or nonbiologic DMARDs. Multivariable analysis was used to estimate the effect of different therapies on the risk of DM. The incidence rates of DM per 1,000 person-years were 8.3 for users of anti-TNF drugs, 13.3 for users of cyclosporine (CSA), 8.4 for users of hydroxychloroquine (HCQ), and 8.1 for users of other nonbiologic DMARDs. Compared with the users of nonbiologic DMARDs, the multivariate-adjusted hazard ratios (aHRs) for DM were significantly lower for those who used anti-TNF drugs with HCQ (aHR: 0.49, 95% confidence interval [CI]: 0.36-0.66) and those who used HCQ alone (aHR: 0.70, 95% CI: 0.63-0.78), but not for those who used anti-TNFs without HCQ (aHR: 1.23, 95% CI: 0.94-1.60) or CSA (aHR: 1.14, 95% CI: 0.77-1.70). The aHR for DM was lowest for pati...Continue Reading

Citations

Jun 21, 2019·QJM : Monthly Journal of the Association of Physicians·T-H ChenJ C-C Wei
Apr 20, 2020·Rheumatology and Therapy·Giacomo Dal BelloGiampiero Girolomoni
Mar 20, 2020·Journal of Diabetes Research·Dawit Zewdu WondafrashKaleab Alemayehu Zewdie
Aug 8, 2021·International Journal of Environmental Research and Public Health·Hung-Chih ChenJames Cheng-Chung Wei

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.