Association between variants in vitamin D-binding protein gene and vitamin D deficiency among pregnant women in china.

Journal of Clinical Laboratory Analysis
Jinju DongJie Deng

Abstract

The prevalence of vitamin D deficiency and insufficiency is extremely high in pregnant women worldwide. However, the association between single nucleotide polymorphisms (SNPs) in vitamin D metabolic pathway genes and 25-hydroxyvitamin D (25(OH)D) concentration among Chinese pregnant women is seldom reported. The risk of adverse neonatal outcomes due to maternal vitamin D deficiency has not been well investigated. A total of 815 pregnant women and 407 infants were enrolled in this study. Serum 25(OH)D concentration was detected. DNA was extracted from the maternal blood for genotyping genetic SNPs in vitamin D pathway. An XGBoost model was established based on SNPs combined with external variables. Mean serum 25(OH)D level was 15.67 ± 7.98 ng/mL among the pregnant women. Seventy-five percent of pregnant women had 25(OH)D deficiency in China. SNPs of GC (rs17467825, rs4588, rs2282679, rs2298850, and rs1155563) were significantly associated with maternal 25(OH)D concentration. The influence of variants of rs17467825, rs4588, rs2282679, and rs2298850 on maternal 25(OH)D might be modified by vitamin D supplementation and sunshine exposure. An XGBoost model was established for monitoring 25(OH)D status in pregnant women and provided ...Continue Reading

References

Jul 18, 2003·The Journal of Biological Chemistry·Jeffrey B ChengDavid W Russell
Mar 10, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ram P GuptaNorman H Bell
Jan 7, 2005·The Journal of Clinical Endocrinology and Metabolism·Silvina LevisBernard A Roos
May 31, 2007·The Journal of Clinical Endocrinology and Metabolism·Lisa M BodnarJames M Roberts
Jul 4, 2007·Diabetes/metabolism Research and Reviews·Elizabeth Ramos-LopezKlaus Badenhoop
Jul 20, 2007·The New England Journal of Medicine·Michael F Holick
Aug 24, 2007·Archives of Disease in Childhood·Adekunle Dawodu, Carol L Wagner
Aug 12, 2008·The American Journal of Clinical Nutrition·Anthony W Norman
Jan 1, 2009·The American Journal of Clinical Nutrition·Marc SinotteJacques Brisson
Apr 1, 2009·The British Journal of Nutrition·Valerie A HolmesJulie M W Wallace
Apr 27, 2010·Human Molecular Genetics·Jiyoung AhnDemetrius Albanes
Sep 25, 2010·Placenta·J S ShinD M Nelson
Jan 26, 2011·Nature Reviews. Endocrinology·Michael F Holick
Mar 2, 2011·Public Health Nutrition·Tirang R NeyestaniBahareh Nikooyeh
Jun 1, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M-S M ArdawiA A Maimani
Jun 28, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Bruce W HollisCarol L Wagner
Apr 18, 2014·The American Journal of Clinical Nutrition·Kristin A MoyDemetrius Albanes
Feb 19, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Handan AlpMevlüt Kürşat Akkar
Jun 23, 2015·Journal of the American College of Nutrition·Carole A BaggerlyAlexander Wunsch
Jul 8, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Xinjuan XuMin Gao
Nov 21, 2015·Public Health Nutrition·Chunfeng YunXiaoguang Yang
Jan 21, 2016·BMC Pregnancy and Childbirth·Åse R EggemoenAnne K Jenum
Aug 26, 2016·Critical Reviews in Food Science and Nutrition·Shreya AgarwalDevendra K Agrawal
Oct 23, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Laura M G MeemsRudolf A de Boer
Nov 20, 2016·Clinical Endocrinology·Padma MurthiPeter R Ebeling
Dec 28, 2016·Canadian Journal of Public Health = Revue Canadienne De Santé Publique·Christy G WoolcottLinda Dodds
Feb 10, 2017·The Journal of Steroid Biochemistry and Molecular Biology·Deena H Elsori, Majeda S Hammoud
Sep 14, 2017·Journal of Clinical Research in Pediatric Endocrinology·Abdurrahman Avar ÖzdemirGünal Bilek
Oct 17, 2017·Journal of Cellular Physiology·Afsane BahramiAmir Avan
Nov 21, 2017·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Bule ShaoYunxian Yu
Dec 16, 2017·BJOG : an International Journal of Obstetrics and Gynaecology·Y ZhangG Cheng
Feb 1, 2018·Journal of Translational Medicine·Massimo MezzavillaNaser Elkum
Apr 11, 2018·BMC Pregnancy and Childbirth·Abdulrahman Al-AjlanNasser M Al-Daghri
Feb 20, 2019·International Journal of Environmental Research and Public Health·Nelfio Di MarcoChristine P Rodda

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Methods Mentioned

BETA
genotyping

Software Mentioned

Python
XGBoost Classifier
XGBoost

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