Association between variation of circulating 25-OH vitamin D and methylation of secreted frizzled-related protein 2 in colorectal cancer.

Clinical Epigenetics
Hatim BoughanemManuel Macias-Gonzalez

Abstract

Colorectal cancer (CRC) results from the accumulation of epigenetic and genetic changes in colon cells during neoplasic transformation, which the activation of Wingless (Wnt) signaling pathway is a common mechanism for CRC initiation. The Wnt pathway is mainly regulated by Wnt antagonists, as secreted frizzled-related protein (SFRP) family. Indeed, SFRP2 is proposed as a noninvasive biomarker for CRC diagnosis. Vitamin D also antagonizes Wnt signaling in colon cancers cells. Several studies showed that vitamin D was able to alter DNA methylation, although this mechanism is not yet clear. Therefore, the aim of this study was to find an association between circulating 25-OH vitamin D (30th percentile of vitamin D) and the SFRP2 methylation. A total of 67 CRC patients were included in the study. These patients were subdivided into two groups based on their 30th percentile vitamin D (20 patients were below, and 47 participants were above the 30th percentile of vitamin D). We investigated the SFRP2 methylation in peripheral blood mononuclear cells (PBMCs), visceral adipose tissue (VAT), CRC tumor tissue, and adjacent tumor-free area. We also determined the relationship between SFRP2 methylation and methylation of carcinogenic and ad...Continue Reading

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Jul 20, 2019·Journal of Clinical Medicine·Amanda Cabrera-MuleroManuel Macias-Gonzalez

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Citations

Oct 8, 2020·Reviews in Endocrine & Metabolic Disorders·Francesco TecilazichAndrea Giustina
Nov 25, 2020·Cancers·José Manuel González-SanchoAlberto Muñoz
Jul 3, 2021·Oncology Reports·Can Kong, Tao Fu
Jul 6, 2021·Critical Reviews in Food Science and Nutrition·Pablo Hernández-AlonsoJordi Salas-Salvadó
Jul 28, 2021·Epigenetics : Official Journal of the DNA Methylation Society·Andrea G IzquierdoAna B Crujeiras
Jul 22, 2021·Molecular Nutrition & Food Research·Hatim BoughanemManuel Macias-Gonzalez

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Datasets Mentioned

BETA
PM00110908

Methods Mentioned

BETA
biopsies
ELISA

Software Mentioned

R

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