Association between Virulence Factors and TRAF1/4-1BB/Bcl-xL Expression in Gastric Mucosa Infected with Helicobacter pylori

Gastroenterology Research and Practice
Fen WangYi Yuan

Abstract

Objective. CagA+/vacAs1+/vacAm1+ Helicobacter pylori upregulates the expression of tumor necrosis factor receptor-associated factor 1 (TRAF1), tumor necrosis factor receptor superfamily member 9 (4-1BB), and B-cell lymphoma-extra large (Bcl-xL) in human gastric epithelial cells. We investigated the correlation between cagA/vacAs1/vacAm1 and TRAF1/4-1BB/Bcl-xL expression in gastric mucosal tissue of patients with gastric disorders. Methods. We collected gastric mucosa samples from 35 chronic, nonatrophic gastritis (CG) patients, 41 atrophic gastritis patients, 44 intestinal metaplasia with atypical hyperplasia (IM) patients, and 28 gastric carcinoma (Ca) patients. The expression of  TRAF1, 4-1BB, and Bcl-xL was determined using western blotting. The expression of cagA, vacAs1, and vacAm1 in H. pylori was examined with polymerase chain reaction. Results. The expression of TRAF1, 4-1BB, and Bcl-xL was significantly upregulated in IM and Ca patients (P < 0.05 compared with CG). There were more cases of cagA+/vacAs1+/vacAm1+ H. pylori infection in samples with elevated TRAF1, 4-1BB, or Bcl-xL expression (P < 0.05). Additionally, there were a remarkably large number of samples with upregulated TRAF1/4-1BB/Bcl-xL expression in cases o...Continue Reading

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Citations

Jun 15, 2016·Toxins·Tran Thi Huyen TrangYoshio Yamaoka
Feb 26, 2016·World Journal of Gastrointestinal Pathophysiology·Rong-Guang ZhangShuai-Yin Chen
Feb 18, 2018·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Meryem BachirKara Turki Douidi
Oct 13, 2015·World Journal of Gastroenterology : WJG·Petra Hudler

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Methods Mentioned

BETA
protein assay
electrophoresis
PCR

Software Mentioned

SPSS

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