Association between Visceral Fat and Bone Mineral Density in Both Male and Female Patients with Adult Growth Hormone Deficiency

Biochemistry Research International
Linman LiGangyi Yang

Abstract

Adult growth hormone deficiency (AGHD) is associated with an increased risk of fractures. The interactions between various body composition and bone are known to be complex in nature. However, very few studies have examined this crosstalk in AGHD. In this study, we sought to investigate the relationship between various parameters of body composition and bone mineral density (BMD) as well as determine the role of visceral fat in determining the bone mass in patients with AGHD. We conducted a cross-sectional study on 57 patients with AGHD. Anthropometry, biochemistry, and analysis of body composition and BMD were performed according to standard protocols. Male and female patients were classified into those with osteoporosis and those without osteoporosis (normal subjects and patients with osteopenia). Further, we analyzed the correlation between the BMD and measurements obtained for various body composition parameters in male and female AGHD patients. Our findings indicated that among female AGHD patients, those with osteoporosis had a significantly higher levels of fat mass (FM) and visceral adipose tissue mass (VATM) (both, P < 0.05) than those without osteoporosis. Further, Pearson correlation analysis showed that the values o...Continue Reading

References

Sep 1, 1992·The Journal of Clinical Endocrinology and Metabolism·I R ReidM C Evans
Oct 1, 1990·Bone and Mineral·C W SlemendaC C Johnston
Apr 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Robert D MurrayStephen M Shalet
Jun 20, 2006·Lancet·Philip Sambrook, Cyrus Cooper
Sep 6, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Lan-Juan ZhaoHong-Wen Deng
Feb 22, 2008·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·H L FideleffP G V Sobrado
Apr 30, 2009·The Journal of Clinical Endocrinology and Metabolism·Youri E C TaesJean-Marc Kaufman
Jun 18, 2009·The Journal of Clinical Endocrinology and Metabolism·Vicente GilsanzSteven D Mittelman
Sep 26, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Paul DimitriNick Bishop
Aug 6, 2013·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Raman Kumar MarwahaKuntal Bhadra
Nov 13, 2013·The Journal of Clinical Endocrinology and Metabolism·Carmine GazzarusoAndrea Giustina
May 13, 2014·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Jun ZhangQifeng Ying
Feb 11, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Natalie A GlassSteven M Levy
Mar 1, 2016·Journal of Obstetrics and Gynaecology of India·Ashok KumarGuresh Kumar
Apr 27, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Y M KimY J Won
Jun 29, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L G MachadoR M R Pereira
Aug 19, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L C PopS A Shapses
Nov 12, 2016·Endocrinology and Metabolism·Mohammad Reza SalamatMohsen Janghorbani
Mar 27, 2018·Annals of Agricultural and Environmental Medicine : AAEM·Anna KęskaMałgorzata Sobczak
Apr 8, 2018·Journal of Molecular Endocrinology·Shoshana YakarClifford J Rosen
Jan 19, 2019·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Yunting WangWei Ren

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