Abstract
Angiotensin converting enzyme inhibitors are effective in delaying the progression of diabetic retinopathy. It is unknown if their use is associated with a better visual outcome in patients with diabetic macular oedema. A non-experimental, comparative, longitudinal and retrospective study was performed on patients with diabetic macular oedema treated by focal photocoagulation, and with systemic arterial hypertension treated with angiotensin converting enzyme inhibitors (Group 1), and without hypertension (Group 2). The dependent variable was the proportion with visual improvement, operatively defined as the gain of one or more lines of vision three weeks after photocoagulation. The independent variable was the use of angiotensin converting enzyme inhibitors. The proportion of eyes with visual improvement after treatment was compared between groups using the Chi squared (χ(2)) test. A total of 33 eyes (51.6%) were assigned to group 1, and 31 (48.2%), to group 2. The mean of visual acuity improved after three weeks, compared with baseline (p=0.002). The proportion of eyes with visual improvement did not differ between patients treated with angiotensin converting enzyme inhibitors (45.5%) and those that did not use them (51.6%, p=...Continue Reading
References
Apr 6, 2002·Diabetologia·I M Hogeboom van BuggenumG J Tangelder
Mar 27, 2003·Investigative Ophthalmology & Visual Science·Ann S WilsonP Elizabeth Rakoczy
Apr 28, 2004·Trends in Endocrinology and Metabolism : TEM·Louise M BurrellMark E Cooper
Sep 17, 2005·The International Journal of Biochemistry & Cell Biology·Jennifer L Wilkinson-Berka
Apr 27, 2007·Korean Journal of Ophthalmology : KJO·Yong Jae Cha, Sung Jin Kim
Jun 27, 2008·Trends in Pharmacological Sciences·Chiara MarchesiErnesto L Schiffrin
Dec 25, 2008·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jeong Hun KimKyu-Won Kim
Jul 3, 2009·The New England Journal of Medicine·Michael MauerRonald Klein
Aug 4, 2009·Eye·A D Wright, P M Dodson
Aug 8, 2009·Experimental Eye Research·Marta VillarroelRafael Simó
Apr 13, 2010·Progress in Retinal and Eye Research·Erica L FletcherJennifer L Wilkinson-Berka
Sep 21, 2010·Diabetes·Antonia G MillerJennifer L Wilkinson-Berka
Jan 18, 2011·International Journal of Clinical Practice·A K SjølieF R R Hobbs
Jul 1, 2011·Diabetes Care·Tasma HarindhanavudhiUNKNOWN Renin Angiotensin System Study (RASS) group
Jul 28, 2011·Molecular Therapy : the Journal of the American Society of Gene Therapy·Amrisha VermaQiuhong Li
Apr 28, 2012·Peptides·Jennifer L Wilkinson-BerkaDevy Deliyanti
Feb 6, 2013·Clinical Science·Jennifer L Wilkinson-BerkaAlex Agrotis
Mar 5, 2013·BMJ Open·John Alexander FordNorman Waugh
Aug 16, 2013·Clinical Ophthalmology·Roderick O'DayMark C Gillies
Jun 24, 2014·Cell & Bioscience·Xinyuan ZhangMark C Gillies
Jul 1, 2014·Retina·Umberto De BenedettoFrancesco Bandello
Oct 3, 2014·World Journal of Cardiology·Pablo Jesus Marin Garcia, Maria Encarna Marin-Castaño
Apr 22, 2015·World Journal of Diabetes·Martin M Nentwich, Michael W Ulbig