Abstract
The objective of the study was to determine the prevalence of vitamin D insufficiency and its association with non-traditional cardiovascular disease (CVD) risk factors such as Apo B in South American Indian school children. A cross-sectional study of 355 children (166 Males) aged 9.6±2.3 y was performed. Anthropometric measures, glucose, lipids, insulin, Apo B, Apo A, and vitamin D concentrations were measured. The prevalence of overweight and obesity was 10.7% (38) per CDC. One child (0.3%) had optimal vitamin D concentrations [25(OH)D[>30 ng/ml. Univariate analysis showed significant associations between vitamin D and HDL-C (r=0.12 p<0.05), age (r=-0.11 p<0.05) BMI (r=-0.22 p<0.05), LDL-C (r=-0.22 p<0.01), triglycerides (r=-0.16 p<0.01), non HDL-C (r=-0.21 p<0.01), Apo B (r=-0.23 p<0.01), Apo B/Apo A (r=-0.21 p<0.01), insulin (r=-0.17 p<0.05), and HOMA-IR (r=-0.16 p<0.05). Multiple linear regression analysis showed that female gender and Apo B were significantly associated with vitamin D adjusted for confounding factors (R(2) 0.12). Vitamin D deficiency was associated with increased Apo B among Indian children, suggesting that it could be used as a risk marker of CVD.
References
Aug 1, 1996·Circulation·B LamarcheJ P Després
Apr 6, 2001·Diabetes Care·K A McAuleyA W Duncan
Jan 5, 2002·Lancet·G WalldiusE Steiner
May 9, 2002·Bone·Anne C LookerN R Sahyoun
Mar 29, 2007·The Journal of Clinical Endocrinology and Metabolism·Anastassios G PittasBess Dawson-Hughes
Jun 30, 2007·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Leanne M WardStanley Zlotkin
Jul 20, 2007·The New England Journal of Medicine·Michael F Holick
Jan 17, 2008·The British Journal of Nutrition·Tom R HillKevin D Cashman
May 7, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·T HagenauP Vestergaard
Jul 22, 2008·Lancet·Matthew J McQueenUNKNOWN INTERHEART study investigators
Aug 8, 2009·Pediatrics·Jared P ReisLawrence J Appel
Aug 8, 2009·Pediatrics·Juhi KumarMichal L Melamed
Jan 13, 2010·Annals of Family Medicine·Kevin Fiscella, Peter Franks
May 21, 2010·The American Journal of Clinical Nutrition·Lisa A HoughtonAnne-Louise M Heath
Oct 12, 2010·The American Journal of Clinical Nutrition·Diane Gilbert-DiamondEduardo Villamor
Mar 4, 2011·The Journal of Clinical Endocrinology and Metabolism·Kumaravel RajakumarSilva A Arslanian
Jul 26, 2011·Journal of Clinical Lipidology·John H ContoisAllan D Sniderman
Jun 5, 2012·The Journal of Pediatrics·Valeria HirschlerUNKNOWN San Antonio de los Cobres Study Group
Jul 3, 2013·Journal of Pediatric Endocrinology & Metabolism : JPEM·Benjamin U NwosuMary M Lee
Citations
Jan 29, 2016·International Journal of Clinical Practice·V Hirschler
Nov 18, 2015·Nutrition Journal·Anna N FuntikovaHelmut Schröder
May 5, 2016·International Journal of Endocrinology·Donatas StakisaitisRimantas Benetis
Feb 7, 2015·International Journal of Food Sciences and Nutrition·Roberto Ercole RusconiCarlo Agostoni
Jun 15, 2019·International Journal of Preventive Medicine·Saeed GhobadiShiva Faghih