Association between Vitamin D and Knee Osteoarthritis: A PRISMA-Compliant Meta-analysis.

Zeitschrift für Orthopädie und Unfallchirurgie
Yinghao YuJijun Zhao

Abstract

Previous investigations showed inconsistent results for associations between vitamin D and knee osteoarthritis (OA). The present study aimed to make a systematic review and meta-analysis for the association between vitamin D and knee OA. We systematically searched for articles published in the databases PubMed, Web of Science, EMBASE, Medline, and Google Scholar through July 2019. All statistical analyses were made using STATA 12.0 software. The Q test and I2 were applied to examine heterogeneities between studies. The study indicated that there were no significant associations between serum levels of 25-hydroxy (OH) vitamin D and prevalence, incidence or progression of knee radiographic OA (ROA), and joint space narrowing (JSN). However, a subgroup study showed significant associations of low vitamin D levels with the progression of knee OA. Additionally, the present study showed no significant effect of vitamin D supplementation on knee OA. The results do not support that serum levels of 25(OH) vitamin D are associated with the risks of knee OA, except perhaps with progression of knee OA. In addition, vitamin D supplementation may not have a clinically significant effect on pain control or structure (tibial cartilage volume a...Continue Reading

References

Mar 15, 2006·Mayo Clinic Proceedings·Michael F Holick
Dec 30, 2006·Arthritis and Rheumatism·David T FelsonSarah L Booth
Aug 6, 2009·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Arjan P BerginkHuibert A P Pols
Feb 23, 2010·International Journal of Surgery·David MoherUNKNOWN PRISMA Group
Dec 31, 2010·International Orthopaedics·Behzad HeidariKaraim Hajian-Tilaki
Jan 18, 2011·Rheumatology International·Leonid Kalichman, Eugene Kobyliansky
Oct 26, 2011·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Khaled F Al-JarallahMohamed A Moussa
Aug 2, 2013·Clinical Orthopaedics and Related Research·Divya SanghiRajeshwar Nath Srivastava
Nov 21, 2014·The Journal of Nutrition·Fang Fang ZhangTimothy E McAlindon
Nov 3, 2015·Seminars in Arthritis and Rheumatism·Arjan P BerginkJoyce B J van Meurs
Aug 20, 2016·Nature Reviews. Rheumatology·William H RobinsonJeremy Sokolove

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Citations

May 28, 2020·Clinical Rheumatology·Margaret L Gourlay, Linda L Gourlay
May 19, 2020·F1000Research·Susanne Grässel, Dominique Muschter

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