Association between Vitamin D Deficiency and Single Nucleotide Polymorphisms in the Vitamin D Receptor and GC Genes and Analysis of Their Distribution in Mexican Postmenopausal Women

Nutrients
Berenice Rivera-ParedezRafael Velázquez-Cruz

Abstract

Genome-wide association studies in people with European ancestry suggest that polymorphisms in genes involved in vitamin D (VD) metabolism have an effect on serum concentrations of 25-hydroxyvitamin D. However, nothing is known about these polymorphisms in populations with Amerindian ancestry. Our aim was to evaluate the association between genetic variants on the vitamin D receptor (VDR) and the vitamin D binding protein (GC) genes, involved in the VD pathway, and VD deficiency in 689 unrelated Mexican postmenopausal women. We also described the frequencies of these variants in 355 postmenopausal women from different ethnic groups. Based on our preliminary results of 400 unrelated Mexican postmenopausal women, three single nucleotide polymorphisms (SNPs) were selected for genotyping. The SNPs rs4516035 in VDR and rs2282679 in GC were associated with VD deficiency. Additionally, women who carried three risk alleles had a 3.67 times higher risk of suffering VD deficiency, compared to women with no risk alleles (p = 0.002). The rs4516035-C allele frequency in the Amerindian population was enriched in the South East region of Mexico. In contrast, the highest frequency of the rs2298850-C allele, a proxy for the tag SNP rs2282679, w...Continue Reading

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Citations

May 6, 2019·Nutrients·Vanessa De la Cruz-GóngoraMario Flores-Aldana
Dec 17, 2020·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Bruna Oliveira MissaggiaMaria Cátira Bortolini
Oct 12, 2021·Lipids in Health and Disease·Yvonne N FloresSteven J Bensinger

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Methods Mentioned

BETA
X-ray
Assay
genotyping
blood
blood collection

Software Mentioned

Illumina GenomeStudio
SDS
HaploView
QGIS
STATA
ENSANUT
R

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