Association between Vitamin D Genetic Risk Score and Cancer Risk in a Large Cohort of U.S. Women

Nutrients
Paulette D ChandlerHoward D Sesso

Abstract

Some observational studies suggest an inverse association between circulating 25-hydroxyvitamin D (25OHD) and cancer incidence and mortality. We conducted a Mendelian randomization analysis of the relationship between a vitamin D genetic risk score (GRS, range 0-10), comprised of five single nucleotide polymorphisms (SNPs) of vitamin D status in the DHCR7, CYP2R1 and GC genes and cancer risk among women. Analysis was performed in the Women's Genome Health Study (WGHS), including 23,294 women of European ancestry who were cancer-free at baseline and followed for 20 years for incident cancer. In a subgroup of 1782 WGHS participants with 25OHD measures at baseline, the GRS was associated with circulating 25OHD mean (SD) = 67.8 (26.1) nmol/L, 56.9 (18.7) nmol/L in the lowest versus 73.2 (27.9) nmol/L in the highest quintile of the GRS (p trend < 0.0001 across quintiles). However, in age-adjusted Cox proportional hazards models, higher GRS (reflecting higher 25OHD levels) was not associated (cases; Hazard Ratio (HR) (95% Confidence Interval (CI)), p-value) with incident total cancer: (n = 3985; 1.01 (1.00-1.03), p = 0.17), breast (n = 1560; 1.02 (0.99-1.05), p = 0.21), colorectal (n = 329; 1.06 (1.00-1.13), p = 0.07), lung (n = 330;...Continue Reading

References

Dec 1, 1989·International Journal of Epidemiology·S SalviniW C Willett
Jul 1, 1985·American Journal of Epidemiology·W C WillettF E Speizer
Feb 24, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D HunterT D Spector
Feb 17, 2006·The New England Journal of Medicine·Jean Wactawski-WendeUNKNOWN Women's Health Initiative Investigators
Aug 30, 2006·Methods in Enzymology·Kevin L GundersonRichard Shen
Jan 24, 2007·The Journal of Steroid Biochemistry and Molecular Biology·Matthias WjstElisabeth André
Sep 22, 2007·Statistics in Medicine·Debbie A LawlorGeorge Davey Smith
Nov 22, 2007·European Journal of Clinical Nutrition·M K SheaS L Booth
Aug 12, 2008·The American Journal of Clinical Nutrition·Sarah-Michelle OrtonGeorge C Ebers
Nov 13, 2008·Journal of the National Cancer Institute·Corey Speers, Powel Brown
Nov 13, 2008·Journal of the National Cancer Institute·Rowan T ChlebowskiUNKNOWN Women's Health Initiative Investigators
Aug 27, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Linda M DongUlrike Peters
Oct 9, 2009·Nature·Teri A ManolioPeter M Visscher
Apr 27, 2010·Human Molecular Genetics·Jiyoung AhnDemetrius Albanes
Nov 9, 2012·Genetic Epidemiology·Linda T HirakiPeter Kraft
Feb 21, 2013·Cancer Research·Elizabeth T JacobsPeter W Jurutka
Jun 29, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Dan WangDian-Wu Liu
Aug 29, 2013·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Linda T HirakiAndrew T Chan
Feb 25, 2014·Cancer Causes & Control : CCC·Fabio PibiriNathan A Ellis
May 3, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Tea SkaabyAllan Linneberg
Dec 30, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Alison M MondulDemetrius Albanes
Mar 31, 2015·Cancer Prevention Research·Paulette D ChandlerJennifer H Lin
Jan 16, 2016·Contemporary Clinical Trials·Shari S BassukJulie E Buring
Jan 31, 2017·International Journal of Environmental Research and Public Health·Cem EkmekciogluMichael Kundi

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Citations

Nov 27, 2018·Bioanalysis·Isaac Mall, Florin Marcel Musteata
Oct 16, 2018·Endocrine Reviews·Roger BouillonJohn Bilezikian
Jun 25, 2019·Endocrine·Ronald B Brown
Mar 20, 2020·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Sonja NeumeyerJenny Chang-Claude
Mar 31, 2021·International Journal of Cancer. Journal International Du Cancer·Jian ZhouDong Hang
Jul 31, 2020·Anti-cancer Agents in Medicinal Chemistry·Afsane Bahrami, Amirhossein Sahebkar

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Methods Mentioned

BETA
genotyping

Software Mentioned

PLINK10
VITAL
SAS

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