Association between vitamin D receptor gene polymorphisms and chronic periodontitis among Libyans

The Libyan Journal of Medicine
Mouna M El JilaniNabil S Enattah

Abstract

Chronic periodontitis (CP) is a common oral disease characterized by inflammation in the supporting tissue of the teeth 'the periodontium', periodontal attachment loss, and alveolar bone loss. The disease has a microbial etiology; however, recent findings suggest that the genetic factors, such as vitamin D receptor (VDR) gene polymorphisms, have also been included. Investigation of the relationship between VDR gene polymorphisms and CP among Libyans. In this study, we examined 196 unrelated Libyans between the ages of 25 and 65 years, including 99 patients and 97 controls. An oral examination based on Ramfjord Index was performed at different dental clinics in Tripoli and information were collected using a self-reported questionnaire. DNA was extracted from buccal swabs; the VDR ApaI, BsmI, and FokI polymorphisms were genotyped using polymerase chain reaction and were sequenced using Sanger Method. A significant difference in the newly detected ApaI SNP C/T rs#731236 was found (p=0.022), whereas no significant differences were found in ApaI SNP G/T rs#7975232, BsmI SNP A/G rs#1544410, and FokI SNP A/G rs#2228570 between patients and controls (p=0.939, 0.466, 0.239), respectively. VDR ApaI SNP C/T rs#731236 may be related to the...Continue Reading

References

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Citations

Jul 22, 2019·Journal of Investigative and Clinical Dentistry·Karthikeyan MurthykumarVijayashree Priyadharsini Jayaseelan
Sep 30, 2016·Clinical and Experimental Dental Research·Anna Maria HeikkinenTimo Sorsa
Feb 14, 2019·BMC Oral Health·Zahra HeidariHamidreza Mahmoudzadeh-Sagheb
Sep 10, 2020·International Journal of Paediatric Dentistry·Mariane C F BarbosaDaniela S B de Oliveira
Nov 27, 2019·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Adam BiczoAron Lazary
May 5, 2021·Acta Odontologica Scandinavica·Thaís Aparecida XavierSandra Yasuyo Fukada
Jul 6, 2021·Saudi Journal of Biological Sciences·Abdullah Ali H AlzahraniAbdulmajeed Abdulghani A Sindi

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Methods Mentioned

BETA
electrophoresis
PCR

Software Mentioned

SPSS
Sequencer Analysis

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