Association Between White Matter Microstructure and Verbal Fluency in Patients With Multiple Sclerosis

Frontiers in Psychology
Tal BlecherMichal Ben-Shachar

Abstract

Verbal fluency refers to the ability to generate words quickly and efficiently according to predefined phonological or semantic criteria. Deficits in verbal fluency limit patients' ability to communicate effectively and to function well in social setups. Multiple sclerosis (MS) patients suffer from various cognitive impairments, and some of them experience language deficits as well. The goal of this study is to examine the contribution of the dorsal and ventral language pathways to verbal fluency in MS patients. All patients (N = 33) underwent diffusion MRI (dMRI) and fluency measurements. Diffusion parameters were calculated along dorsal and ventral language-related pathways and their right-hemispheric homologs, identified individually in each patient. Significant correlations were found between fluency measures and mean fractional anisotropy (FA) in several pathways, including the left fronto-temporal arcuate fasciculus (AFft), bilateral inferior fronto-occipital fasciculus (IFOF), and bilateral frontal aslant tract. Along-tract correlations revealed a more selective pattern of associations: letter-based fluency was associated with FA in a segment of the left AFft (dorsal pathway), while category-based fluency was associated ...Continue Reading

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Citations

Jun 20, 2020·Neurological Research·Zafer KeserFlavia M Nelson
Feb 9, 2021·Frontiers in Neurology·Alfonso Delgado-ÁlvarezJorge Matias-Guiu
Feb 25, 2021·Multiple Sclerosis and Related Disorders·Amy L LebkuecherLauren B Strober
Mar 19, 2021·Frontiers in Neurology·Emanuele La CorteGraziano Serrao
Apr 2, 2021·Scientific Reports·Patrizia TurrizianiMassimiliano Oliveri
May 25, 2021·Frontiers in Aging Neuroscience·Alar KaskikallioPetra Grönholm-Nyman

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Methods Mentioned

BETA
imaging techniques

Software Mentioned

MindStreams
AFQ
Automatic Fiber Quantification ( “ AFQ ” )
mrDiffusion
MATLAB
Quench
SPM5
pc
MS Analyze
ac

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