Association between white opaque substance under magnifying colonoscopy and lipid droplets in colorectal epithelial neoplasms

World Journal of Gastroenterology : WJG
Keisuke KawasakiTakayuki Matsumoto

Abstract

To examine the association between white opaque substance (WOS) and histologically verified lipid droplets in colorectal epithelial neoplasms. We reviewed colonoscopy records at our institution from 2014 to 2016 and identified cases of endoscopically or surgically resected colorectal epithelial neoplasms observed by magnifying narrow-band imaging (M-NBI) colonoscopy. Immunohistochemistry was used to stain tumors with a monoclonal antibody specific to adipophilin as a marker of lipids. The expression and distribution of adipophilin were compared between WOS-positive and WOS-negative lesions and among tumors classified by histologic type and depth of invasion. Under M-NBI colonoscopy, 81 lesions were positive for WOS and 48 lesions were negative for WOS. The rate of adipophilin expression was significantly higher in WOS-positive lesions (95.1%) than in WOS-negative lesions (68.7%) (P = 0.0001). The incidence of deep adipophilin expression was higher in WOS-positive lesions (24.7%) than in WOS-negative lesions (4.2%) (P = 0.001). The incidence of deep expression was predominant among cancers with massive submucosal invasion (62.5%) compared to adenoma (7.2%) and high-grade dysplasia or cancers with slight submucosal invasion (12.7...Continue Reading

References

Oct 20, 2012·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Kenshi YaoMunechika Enjoji
Feb 2, 2013·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Tetsuya UeoShigeo Yokoyama
Jul 19, 2013·World Journal of Gastroenterology : WJG·Hiroya UeyamaSumio Watanabe
Jul 22, 2014·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Shunsuke YoshiiTetsuo Takehara
Dec 31, 2015·Endoscopy International Open·Tetsuya UeoKazunari Murakami

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Citations

Mar 8, 2020·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Keisuke KawasakiTakayuki Matsumoto
Feb 8, 2020·Cell Death & Disease·André L S CruzPatricia T Bozza
Jan 10, 2021·Clinical Journal of Gastroenterology·Tomomasa TochioRyoji Kushima

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Methods Mentioned

BETA
dissection
biopsy

Software Mentioned

JMP

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